Detalhe da pesquisa
1.
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Nat Genet
; 35(1): 76-83, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12881722
2.
Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin.
Mol Biol Evol
; 25(2): 330-8, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18048403
3.
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.
J Neurosci
; 27(26): 6972-83, 2007 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17596446
4.
Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease.
Brain Pathol
; 18(2): 225-38, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18093249
5.
Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae.
BMC Dev Biol
; 7: 127, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18005438
6.
Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.
J Neurosci
; 25(43): 9932-9, 2005 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16251441
7.
Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus.
BMC Genomics
; 7: 288, 2006 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17092333
8.
The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases.
Ann N Y Acad Sci
; 1049: 39-50, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15965106
9.
An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.
Nat Neurosci
; 15(5): 713-21, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22466506
10.
Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease.
J Biol Chem
; 283(9): 5780-9, 2008 Feb 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18156184
11.
Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators.
J Biol Chem
; 282(34): 24554-62, 2007 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-17565993
12.
No evidence of association between BDNF gene variants and age-at-onset of Huntington's disease.
Neurobiol Dis
; 24(2): 274-9, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16905325
13.
Normal huntingtin function: an alternative approach to Huntington's disease.
Nat Rev Neurosci
; 6(12): 919-30, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16288298
14.
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease.
Pharmacol Res
; 52(2): 140-50, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15967379
15.
From target identification to drug screening assays for neurodegenerative diseases.
Pharmacol Res
; 52(3): 245-51, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15916902
16.
Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery.
Pharmacol Res
; 52(2): 133-9, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15967378
17.
Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain.
Eur J Neurosci
; 18(5): 1093-102, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12956709
18.
Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons.
J Biol Chem
; 277(42): 39594-8, 2002 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12200414