Cryptogenic fibrosing alveolitis and lung cancer: the BTS study.

BACKGROUND: The risk of lung cancer is often reported to be increased for patients with cryptogenic fibrosing alveolitis (CFA). METHODS: Vital status was sought for all 588 members of the British Thoracic Society (BTS) cryptogenic fibrosing alveolitis (CFA) study 11 years after entry to the cohort. Observed deaths due to lung cancer were compared with expected deaths using age-, sex- and period-adjusted national rates. The roles of reported asbestos exposure and smoking were also investigated. RESULTS: 488 cohort members (83%) had died; 46 (9%) were certified to lung cancer (ICD9 162). The standardised mortality ratio (SMR) was 7.4 (95% CI 5.4 to 9.9). Stratified analysis showed increased lung cancer mortality among younger subjects, men and ever smokers. Using an independent expert panel, 25 cohort members (4%) were considered to have at least moderate exposure to asbestos; the risk of lung cancer was increased for these subjects (SMR 13.1 (95% CI 3.6 to 33.6)) vs 7.2 (95% CI 5.2 to 9.7) for those with less or no asbestos exposure). Ever smoking was reported by 448 (73%) of the cohort and was considerably higher in men than in women (92% vs 49%; p<0.001). Most persons who died from lung cancer were male (87%), and all but two (96%) had ever smoked. Ever smokers presented at a younger age (mean 67 vs 70 years; p<0.001) and with less breathlessness (12% smokers reported no breathlessness vs 5% never smokers; p = 0.02). CONCLUSIONS: These findings confirm an association between CFA and lung cancer although this relationship may not be causal. The high rate of smoking and evidence that smokers present for medical attention earlier than non-smokers suggest that smoking could be confounding this association.

Evidence based guidelines for the prevention, identification, and management of occupational asthma.

BACKGROUND: Occupational asthma is the most frequently reported work related respiratory disease in many countries. This work was commissioned by the British Occupational Health Research Foundation to assist the Health and Safety Executive in achieving its target of reducing the incidence of occupational asthma in Great Britain by 30% by 2010. AIM: The guidelines aim to improve the prevention, identification, and management of occupational asthma by providing evidence based recommendations on which future practice can be based. METHODS: The literature was searched systematically using Medline and Embase for articles published in all languages up to the end of June 2004. Evidence based statements and recommendations were graded according to the Royal College of General Practitioner's star system and the revised Scottish Intercollegiate Guidelines Network grading system. RESULTS: A total of 474 original studies were selected for appraisal from over 2500 abstracts. The systematic review produced 52 graded evidence statements and 22 recommendations based on 223 studies. DISCUSSION: Evidence based guidelines have become benchmarks for practice in healthcare and the process used to prepare them is well established. This evidence review and its recommendations focus on interventions and outcomes to provide a robust approach to the prevention, identification, and management of occupational asthma, based on and using the best available medical evidence. The most important action to prevent cases of occupational asthma is to reduce exposure at source. Thereafter surveillance should be performed for the early identification of symptoms, including occupational rhinitis, with additional functional and immunological tests where appropriate. Effective management of workers suspected to have occupational asthma involves the identification and investigation of symptoms suggestive of asthma immediately they occur. Those workers who are confirmed to have occupational asthma should be advised to avoid further exposure completely and early in the course of their disease to offer the best chance of recovery.

HLA phenotype and exposure in development of occupational asthma.

OBJECTIVE: To review relevant scientific literature to understand the contribution of exposure to the risk of developing occupational asthma and whether HLA class 2 molecules contribute to individual susceptibility to sensitization and asthma caused by low-molecular-weight chemicals. STUDY SELECTION: The author's expert opinion was used to select relevant articles based on systematic reviews of relevant literature. RESULTS: Studies during the past decade have shown that intensity of exposure is an important determinant of asthma induced by inhaled respiratory sensitizers, both proteins and low-molecular-weight chemicals. There is evidence that HLA class 2 alleles contribute to the risk of sensitization and asthma caused by low-molecular-weight chemical sensitizers. HLA-DR3 is associated with an increased risk of developing specific IgE to trimellic anhydride (TMA) and complex platinum salts such as ammonium hexachloroplate (ACP). In those exposed to ACP and possibly also to TMA, risk is greater in those who have experienced lower intensity of exposure. CONCLUSIONS: Exposure intensity is an important determinant of sensitization and asthma caused by respiratory sensitizers. HLA class 2 alleles contribute to individual susceptibility to low-molecular-weight chemicals. For some chemicals, the contribution of HLA class 2 alleles is greater in those less exposed at work to the relevant chemical.