Detalhe da pesquisa
1.
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506.
Bioorg Med Chem Lett
; 94: 129456, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37633618
2.
Ligand conjugate SAR and enhanced delivery in NHP.
Mol Ther
; 29(10): 2910-2919, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34091052
3.
Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates.
Nature
; 521(7552): 362-5, 2015 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901685
4.
Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates.
J Infect Dis
; 214(suppl 3): S367-S374, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571900
5.
Identification of the Mycobacterium tuberculosis protein PE-PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression.
Cell Microbiol
; 15(5): 795-808, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23167250
6.
Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161.
Viruses
; 16(3)2024 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38543689
7.
Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2.
ACS Infect Dis
; 10(5): 1780-1792, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38651692
8.
Measuring hepatitis B pgRNA stability using an updated automated HBV pgRNA assay with increased sensitivity.
Hepatol Commun
; 7(4)2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36930867
9.
Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles.
Nanomedicine
; 8(3): 328-36, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21718674
10.
The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly.
RSC Med Chem
; 13(3): 343-349, 2022 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35434625
11.
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis B.
Hepatol Commun
; 6(12): 3457-3472, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36194181
12.
Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1.
Nat Commun
; 12(1): 1222, 2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619272
13.
Sleeping with the enemy: how intracellular pathogens cope with a macrophage lifestyle.
PLoS Pathog
; 8(3): e1002551, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22457616
14.
Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model.
ACS Infect Dis
; 5(5): 738-749, 2019 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30408957
15.
ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection.
ACS Infect Dis
; 5(5): 725-737, 2019 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403127
16.
Characterization of Aedes Dredd: a novel initiator caspase from the yellow fever mosquito, Aedes aegypti.
Insect Biochem Mol Biol
; 37(6): 559-69, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17517333
17.
siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease.
J Clin Invest
; 127(12): 4437-4448, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29106386
18.
Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA.
Nat Microbiol
; 1(10): 16142, 2016 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27670117
19.
Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA.
Sci Transl Med
; 6(250): 250ra116, 2014 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25143366
20.
Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles.
Future Microbiol
; 8(3): 403-11, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23464375