Detalhe da pesquisa
1.
Mechanistic Insights into Roseoflavin Synthesis by N,N-8-Demethyl-8-aminoriboflavin Dimethyltransferase (RosA): Molecular Dynamics Simulations and Residue Conservation Analysis.
J Chem Inf Model
; 63(12): 3903-3910, 2023 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310018
2.
Tuning of pKa values activates substrates in flavin-dependent aromatic hydroxylases.
J Biol Chem
; 295(12): 3965-3981, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32014994
3.
Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.
Hum Mol Genet
; 24(20): 5697-710, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26206890
4.
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.
Biochim Biophys Acta Mol Basis Dis
; 1863(1): 188-199, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27769936
5.
Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability.
Hum Mol Genet
; 23(15): 4015-23, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24626631
6.
The reaction kinetics of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1 provide an understanding of the para-hydroxylation enzyme catalytic cycle.
J Biol Chem
; 288(49): 35210-21, 2013 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24129570
7.
pH-dependent studies reveal an efficient hydroxylation mechanism of the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase.
J Biol Chem
; 286(1): 223-33, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21030590
8.
Interactions with the substrate phenolic group are essential for hydroxylation by the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase.
J Biol Chem
; 286(52): 44491-502, 2011 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22052902
9.
10.
3,4-Dihydroxyphenylacetate 2,3-dioxygenase from Pseudomonas aeruginosa: An Fe(II)-containing enzyme with fast turnover.
PLoS One
; 12(2): e0171135, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28158217
11.
A Single-Site Mutation at Ser146 Expands the Reactivity of the Oxygenase Component of p-Hydroxyphenylacetate 3-Hydroxylase.
ACS Chem Biol
; 11(10): 2889-2896, 2016 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27541707
12.
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.
FEBS J
; 283(8): 1531-49, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26913589