Detalhe da pesquisa
1.
Effect of attachment site on stability of cleavable antibody drug conjugates.
Bioconjug Chem
; 26(4): 650-9, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25643134
2.
ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.
Cancer Immunol Res
; 12(5): 592-613, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38393969
3.
Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates.
Sci Rep
; 9(1): 2443, 2019 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30792442
4.
RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models.
Oncotarget
; 9(71): 33446-33458, 2018 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30323890
5.
Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model.
Neuro Oncol
; 9(3): 259-70, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17522330
6.
A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies.
Blood Adv
; 1(15): 1088-1100, 2017 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29296751
7.
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Mol Cancer Ther
; 15(5): 958-70, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944918
8.
RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models.
Mol Cancer Ther
; 15(11): 2698-2708, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27582525
9.
Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.
PLoS One
; 10(7): e0132282, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26161543
10.
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.
Chem Biol
; 20(2): 161-7, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23438745
11.
Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.
Nat Biotechnol
; 33(7): 694-6, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26154005
12.
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
J Med Chem
; 52(6): 1518-21, 2009 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19231864
13.
Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.
Mol Pharmacol
; 70(2): 518-31, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16707625
14.
p38 alpha mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats.
J Cardiovasc Pharmacol
; 44(4): 486-92, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15454858