RESUMO
We studied the characteristics of strains isolated from neonates with group B streptococci sepsis and meningitis, before and after the introduction of antibiotic prophylaxis in The Netherlands. In 1999, 1 year after this introduction the serotype and genotype distribution and the susceptibility patterns of the GBS strains had not changed. Penicillins remain drugs of first choice to prevent and treat neonatal GBS disease.
Assuntos
Antibacterianos/farmacologia , Antibioticoprofilaxia , Meningites Bacterianas/microbiologia , Sepse/microbiologia , Infecções Estreptocócicas/microbiologia , Streptococcus agalactiae/classificação , Streptococcus agalactiae/efeitos dos fármacos , Técnicas de Tipagem Bacteriana , Genótipo , Humanos , Recém-Nascido , Meningites Bacterianas/prevenção & controle , Testes de Sensibilidade Microbiana , Países Baixos , Sorotipagem , Infecções Estreptocócicas/prevenção & controle , Streptococcus agalactiae/isolamento & purificaçãoRESUMO
We sent a questionnaire to all members of the European Society for Paediatric Infectious Diseases and to all delegates of the European Association of Perinatal Medicine to determine existing policies for prevention of neonatal group B streptococcal (GBS) infection in Europe. The incidence of GBS colonization in pregnant women and of neonatal GBS infection varies. Policies for prevention of GBS infection are not well-developed.
Assuntos
Transmissão Vertical de Doenças Infecciosas/prevenção & controle , Complicações Infecciosas na Gravidez/prevenção & controle , Infecções Estreptocócicas/prevenção & controle , Streptococcus agalactiae/isolamento & purificação , Controle de Doenças Transmissíveis/organização & administração , Europa (Continente)/epidemiologia , Feminino , Inquéritos Epidemiológicos , Humanos , Incidência , Recém-Nascido , Masculino , Pediatria , Gravidez , Complicações Infecciosas na Gravidez/epidemiologia , Prevenção Primária , Medição de Risco , Sociedades Médicas , Infecções Estreptocócicas/epidemiologia , Inquéritos e Questionários , Taxa de SobrevidaRESUMO
Group B streptococcal (GBS) infection is still an important cause of morbidity and mortality in newborn infants. In The Netherlands, there are no published data on the incidence of neonatal GBS infection. We collected data of all infants with GBS disease during the first 3 months of life, as reported to the Dutch Paediatric Surveillance Unit (DPSU) during a period of 2 years (1997-98). Neonates with early-onset GBS disease (both sepsis and probable sepsis) were included for further analysis. The level of completeness of the DPSU data was determined by capture-recapture techniques. The incidence of early-onset GBS disease in The Netherlands in 1997-98, as calculated from the DPSU data, was 0.9 per 1000 live births. After correction for under-reporting, the incidence was estimated to be 1.9 per 1000 live births. The case fatality rate of early-onset GBS disease was only 5%. Despite the decrease in the mortality rate during the last decades, it remains a serious condition with potential irreversible brain damage. Therefore, formal guidelines for the prevention of neonatal early-onset GBS disease in The Netherlands were introduced in 1999. The data collected in this study may serve as baseline data for evaluation of the effect of these guidelines.