Detalhe da pesquisa
1.
Ultrasensitive Detection of Aß42 Seeds in Cerebrospinal Fluid with a Nanopipette-Based Real-Time Fast Amyloid Seeding and Translocation Assay.
Anal Chem
; 95(34): 12623-12630, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37587130
2.
G protein-coupled receptors can control the Hippo/YAP pathway through Gq signaling.
FASEB J
; 35(7): e21668, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34114695
3.
Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.
Anal Chem
; 93(15): 6104-6111, 2021 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33825439
4.
The pharmacologic characterization of allosteric molecules: Gq protein activation.
J Recept Signal Transduct Res
; 39(2): 106-113, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-31322035
5.
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol
; 13(4): 372-380, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28135236
6.
Equilibrium Assays Are Required to Accurately Characterize the Activity Profiles of Drugs Modulating Gq-Protein-Coupled Receptors.
Mol Pharmacol
; 94(3): 992-1006, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29954837
7.
Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.
Proc Natl Acad Sci U S A
; 112(5): 1601-6, 2015 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25605885
8.
Multicolor time-resolved Förster resonance energy transfer microscopy reveals the impact of GPCR oligomerization on internalization processes.
FASEB J
; 29(6): 2235-46, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25690655
9.
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.
Proc Natl Acad Sci U S A
; 110(15): E1416-25, 2013 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23487753
10.
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
Proc Natl Acad Sci U S A
; 110(4): 1512-7, 2013 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23297228
11.
Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation.
EMBO J
; 30(1): 32-42, 2011 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21063387
12.
The oligomeric state sets GABA(B) receptor signalling efficacy.
EMBO J
; 30(12): 2336-49, 2011 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21552208
13.
Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy.
Proc Natl Acad Sci U S A
; 109(17): 6733-8, 2012 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22493271
14.
A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.
Mol Pharmacol
; 84(6): 854-64, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24061855
15.
Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration.
EMBO J
; 28(15): 2195-208, 2009 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19590495
16.
Fluorescent ligands to investigate GPCR binding properties and oligomerization.
Biochem Soc Trans
; 41(1): 148-53, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23356275
17.
Design and validation of a homogeneous time-resolved fluorescence-based leptin receptor binding assay.
Anal Biochem
; 436(1): 1-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23333588
18.
Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting.
FASEB J
; 26(8): 3430-9, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22613777
19.
Concerted conformational changes control metabotropic glutamate receptor activity.
Sci Adv
; 9(22): eadf1378, 2023 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37267369
20.
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.
J Biol Chem
; 286(12): 9985-97, 2011 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21247891