RESUMO
Breast cancer (BC) is the most common cause of cancer-related death in women worldwide. Several ABCB1 and VEGFA gene polymorphisms, such as ABCB1-G1199â¯T/A (rs2229109), VEGFA -634â¯Gâ¯>â¯C (rs2010963), VEGFA 2578 Câ¯>â¯A (rs699947) and VEGFA 7 Câ¯>â¯T (rs25648) have been associated with risk of BC and clinical outcomes. The purpose of this study was to evaluate the association between these gene polymorphisms and BC risk and prognosis. A retrospective case-control study was conducted, including 84 BC cases and 119 controls of Spanish (European, Caucasian) origin. ABCB1-G1199â¯T/A (rs2229109), VEGFA -634â¯Gâ¯>â¯C (rs2010963), VEGFA 2578 Câ¯>â¯A (rs699947) and VEGFA 7 Câ¯>â¯T (rs25648) gene polymorphisms were analysed by TaqMan®. The genotypic logistic regression model adjusted by aged revealed no association with any of the polymorphisms and BC risk, although the C-allele of VEGFA 2578 Câ¯>â¯A showed a trend to higher BC risk in the allelic and recessive models (pâ¯=â¯0.055 and 0.054, respectively). There was no influence of these gene polymorphisms on overall survival (OS). The univariate Cox model showed that carriers of the A-allele for VEGFA 2578 Câ¯>â¯A tended to have longer OS compared to CC patients (CC vs A-allele Hazard ratio (HR): 2.08; CI95 %â¯=â¯0.96-4.49; pâ¯=â¯0.0587). There was no association between the gene polymorphisms analysed and disease-free survival (DFS). The univariate Cox model showed a trend toward a longer DFS in patients carrying ABCB1-G1199â¯T/A GG genotype compared to those with A-allele (GG vs A-allele HR: 0.43; CI95 %â¯=â¯0.18-1.03; pâ¯=â¯0.0612). No influence of ABCB1-G1199â¯T/A (rs2229109), VEGFA -634â¯Gâ¯>â¯C (rs2010963), VEGFA 2578 Câ¯>â¯A (rs699947) and VEGFA 7 Câ¯>â¯T (rs25648) gene polymorphisms on risk of developing BC was found in our study. There was no association between the polymorphisms studied and DFS and OS.