Detalhe da pesquisa
1.
An expanded universe of cancer targets.
Cell
; 184(5): 1142-1155, 2021 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33667368
2.
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Cell
; 177(4): 1067-1079.e19, 2019 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31051099
3.
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Cell
; 170(1): 199-212.e20, 2017 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28666119
4.
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat Chem Biol
; 15(6): 565-574, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31086331
5.
Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in ß-Cells.
J Am Chem Soc
; 142(14): 6477-6482, 2020 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32175731
6.
Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.
Proc Natl Acad Sci U S A
; 114(20): E4030-E4039, 2017 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461505
7.
Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in ß-Cells.
Int J Mol Sci
; 21(21)2020 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33137873
8.
Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.
J Biol Chem
; 292(43): 17598-17608, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28860191
9.
Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.
Trends Genet
; 31(1): 16-23, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25498789
10.
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
Nat Chem Biol
; 12(2): 102-8, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26656089
11.
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Nat Chem Biol
; 12(2): 109-16, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26656090
12.
Real-Time Biological Annotation of Synthetic Compounds.
J Am Chem Soc
; 138(28): 8920-7, 2016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27398798
13.
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
J Am Chem Soc
; 137(24): 7929-34, 2015 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26042473
14.
Target identification and mechanism of action in chemical biology and drug discovery.
Nat Chem Biol
; 9(4): 232-40, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23508189
15.
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.
Proc Natl Acad Sci U S A
; 109(38): 15115-20, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22949699
16.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Proc Natl Acad Sci U S A
; 109(14): 5364-9, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22434908
17.
Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.
Proc Natl Acad Sci U S A
; 108(17): 6817-22, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21482810
18.
KD025 Is a Casein Kinase 2 Inhibitor That Protects Against Glucolipotoxicity in ß-Cells.
Diabetes
; 73(4): 585-591, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38211571
19.
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.
Proc Natl Acad Sci U S A
; 107(44): 18787-92, 2010 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20956335
20.
Small-molecule inducers of insulin expression in pancreatic alpha-cells.
Proc Natl Acad Sci U S A
; 107(34): 15099-104, 2010 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20696901