Detalhe da pesquisa
1.
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies.
Bioorg Med Chem Lett
; 26(12): 2920-2926, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27158141
2.
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Bioorg Med Chem Lett
; 26(11): 2724-9, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27086121
3.
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.
Proc Natl Acad Sci U S A
; 110(30): 12426-31, 2013 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23836671
4.
A reversed sulfonamide series of selective RORc inverse agonists.
Bioorg Med Chem Lett
; 24(24): 5769-5776, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453817
5.
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.
Arthritis Rheum
; 65(8): 2161-71, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23666743
6.
Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Bioorg Med Chem Lett
; 23(5): 1238-44, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374866
7.
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett
; 23(12): 3592-8, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642482
8.
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Bioorg Med Chem Lett
; 22(13): 4296-302, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22672799
9.
Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase.
ACS Med Chem Lett
; 11(4): 497-505, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292556
10.
Towards improving compound selection in structure-based virtual screening.
Drug Discov Today
; 13(5-6): 219-26, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18342797
11.
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.
Cell Rep
; 22(13): 3641-3659, 2018 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29590629
12.
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J Med Chem
; 61(23): 10767-10792, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403352
13.
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
F1000Res
; 5: 1005, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27429741
14.
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
ACS Chem Biol
; 11(11): 3179-3190, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689388
15.
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J Med Chem
; 59(24): 11120-11137, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002956
16.
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Eur J Med Chem
; 112: 20-32, 2016 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26874741
17.
Structure-based approaches to drug design and virtual screening.
Curr Opin Drug Discov Devel
; 5(3): 407-13, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12058616
18.
PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.
J Med Chem
; 45(6): 1221-32, 2002 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11881991
19.
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
J Med Chem
; 56(16): 6352-70, 2013 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23859074
20.
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
J Med Chem
; 55(12): 5901-21, 2012 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22591402