Detalhe da pesquisa
1.
The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites.
PLoS Biol
; 19(12): e3001483, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34879056
2.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
3.
The Plasmodium Lactate/H+ Transporter PfFNT Is Essential and Druggable In Vivo.
Antimicrob Agents Chemother
; 67(8): e0035623, 2023 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37428074
4.
Key Contributions by the Swiss Tropical and Public Health Institute Towards New and Better Drugs for Tropical Diseases.
Chimia (Aarau)
; 77(9): 593-602, 2023 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38047835
5.
Our Exciting Journey to ACT-451840.
Chimia (Aarau)
; 75(11): 916-922, 2021 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34798913
6.
Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Malar J
; 19(1): 365, 2020 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33046062
7.
Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559138
8.
Two successful decades of Swiss collaborations to develop new anti-malarials.
Malar J
; 18(1): 94, 2019 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902051
9.
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay.
Malar J
; 18(1): 427, 2019 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31849323
10.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
11.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
12.
3D-QSAR Modeling and Synthesis of New Fusidic Acid Derivatives as Antiplasmodial Agents.
J Chem Inf Model
; 58(8): 1553-1560, 2018 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30040885
13.
CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
Mol Microbiol
; 101(3): 381-93, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073104
14.
Probing the Peroxycarbenium [3+2] Cycloaddition Reactions with 1,2-Disubstituted Ethylenes: Results and Insights.
Chemistry
; 23(9): 2031-2034, 2017 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012253
15.
In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.
Malar J
; 16(1): 45, 2017 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28122617
16.
Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.
Bioorg Med Chem Lett
; 27(3): 658-661, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012840
17.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
18.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
19.
Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase.
Antimicrob Agents Chemother
; 60(1): 115-25, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26459907
20.
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.
J Chem Inf Model
; 56(3): 548-62, 2016 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26915022