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1.
Nucleic Acids Res ; 47(D1): D464-D474, 2019 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-30357411

RESUMO

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, rcsb.org), the US data center for the global PDB archive, serves thousands of Data Depositors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and without usage restrictions to more than 1 million rcsb.org Users worldwide and 600 000 pdb101.rcsb.org education-focused Users around the globe. PDB Data Depositors include structural biologists using macromolecular crystallography, nuclear magnetic resonance spectroscopy and 3D electron microscopy. PDB Data Consumers include researchers, educators and students studying Fundamental Biology, Biomedicine, Biotechnology and Energy. Recent reorganization of RCSB PDB activities into four integrated, interdependent services is described in detail, together with tools and resources added over the past 2 years to RCSB PDB web portals in support of a 'Structural View of Biology.'


Assuntos
Bases de Dados de Proteínas , Conformação Proteica , Pesquisa Biomédica/educação , Biotecnologia/educação , Curadoria de Dados , Software
2.
Nucleic Acids Res ; 45(D1): D271-D281, 2017 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-27794042

RESUMO

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, http://rcsb.org), the US data center for the global PDB archive, makes PDB data freely available to all users, from structural biologists to computational biologists and beyond. New tools and resources have been added to the RCSB PDB web portal in support of a 'Structural View of Biology.' Recent developments have improved the User experience, including the high-speed NGL Viewer that provides 3D molecular visualization in any web browser, improved support for data file download and enhanced organization of website pages for query, reporting and individual structure exploration. Structure validation information is now visible for all archival entries. PDB data have been integrated with external biological resources, including chromosomal position within the human genome; protein modifications; and metabolic pathways. PDB-101 educational materials have been reorganized into a searchable website and expanded to include new features such as the Geis Digital Archive.


Assuntos
Biologia Computacional/métodos , Bases de Dados Genéticas , Proteínas/química , Proteínas/genética , Conjuntos de Dados como Assunto , Redes e Vias Metabólicas , Modelos Moleculares , Conformação Proteica , Proteínas/metabolismo , Software , Relação Estrutura-Atividade , Interface Usuário-Computador , Navegador
3.
Nucleic Acids Res ; 43(Database issue): D345-56, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25428375

RESUMO

The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide. Our efforts over the past 2 years focused on enabling a deeper understanding of structural biology and providing new structural views of biology that support both basic and applied research and education. Herein, we describe recently introduced data annotations including integration with external biological resources, such as gene and drug databases, new visualization tools and improved support for the mobile web. We also describe access to data files, web services and open access software components to enable software developers to more effectively mine the PDB archive and related annotations. Our efforts are aimed at expanding the role of 3D structure in understanding biology and medicine.


Assuntos
Bases de Dados de Proteínas , Conformação Proteica , Sítios de Ligação , Internet , Proteínas de Membrana/química , Biologia Molecular/educação , Anotação de Sequência Molecular , Complexos Multiproteicos/química , Peptídeos/química , Preparações Farmacêuticas/química , Pesquisa , Software
4.
J Matern Fetal Neonatal Med ; 29(15): 2423-7, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26429503

RESUMO

OBJECTIVE: To determine whether a reinforcing cerclage (RC) for a short cervix measured after the primary cerclage procedure prolonged pregnancy. METHODS: We conducted a retrospective cohort study of 157 women with singleton gestations who underwent cerclage for standard indications. Women were grouped according to cervical length (CL) at the time of follow-up 1-2 weeks after the initial cerclage placement: ≥25 mm (106 women) and <25 mm with (20 women) or without RC (31 women). Gestational age (GA) at delivery was compared by ANOVA. Survival risk analysis was applied to model GA at delivery adjusted for indication and CL before and after the first cerclage. RESULTS: Women with CL ≥25mm delivered later than women with CL < 25mm after the first cerclage (p < 0.01). RC did not delay delivery for women with CL < 25 mm (p = 0.17) after the primary procedure. Indication for the primary cerclage (p < 0.01) and CL (p < 0.01) after the primary cerclage were the best predictors for GA at delivery. CONCLUSION: Placement of RC for short cervix did not prolong duration of pregnancy, GA at delivery or modify the probability of preterm birth.


Assuntos
Cerclagem Cervical/métodos , Colo do Útero/cirurgia , Doenças do Colo do Útero/cirurgia , Adulto , Estudos de Coortes , Feminino , Seguimentos , Idade Gestacional , Humanos , Gravidez , Resultado da Gravidez , Estudos Retrospectivos , Análise de Sobrevida
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