Detalhe da pesquisa
1.
Development of minimal physiologically-based pharmacokinetic-pharmacodynamic models for characterizing cellular kinetics of CAR T cells following local deliveries in mice.
J Pharmacokinet Pharmacodyn
; 49(5): 525-538, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35869348
2.
Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
Drug Metab Dispos
; 48(3): 217-229, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31911485
3.
A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys.
J Pharmacol Exp Ther
; 370(2): 182-196, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085699
4.
Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.
Xenobiotica
; 49(7): 852-862, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30132394
5.
A phase I study to assess the mass balance, excretion, and pharmacokinetics of [14C]-ixazomib, an oral proteasome inhibitor, in patients with advanced solid tumors.
Invest New Drugs
; 36(3): 407-415, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28932928
6.
Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP).
Xenobiotica
; 48(5): 467-477, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28485193
7.
Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles.
Xenobiotica
; 48(11): 1173-1183, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29098941
8.
Quantification of Four Efflux Drug Transporters in Liver and Kidney Across Species Using Targeted Quantitative Proteomics by Isotope Dilution NanoLC-MS/MS.
Pharm Res
; 33(9): 2280-8, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27356525
9.
Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles.
Bioorg Med Chem Lett
; 26(2): 551-555, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26642765
10.
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.
Drug Metab Dispos
; 41(7): 1347-66, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620485
11.
Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.
Drug Metab Dispos
; 41(7): 1367-74, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620486
12.
PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper.
AAPS J
; 25(5): 78, 2023 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523051
13.
Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation.
Mol Pharmacol
; 82(6): 1008-21, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22826468
14.
Predicting Approximate Clinically Effective Doses in Oncology Using Preclinical Efficacy and Body Surface Area Conversion: A Retrospective Analysis.
Front Pharmacol
; 13: 830972, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35559235
15.
The Perspective of DMPK on Recombinant Adeno-Associated Virus-Based Gene Therapy: Past Learning, Current Support, and Future Contribution.
AAPS J
; 24(1): 31, 2022 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-35102450
16.
Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development.
Acta Pharm Sin B
; 12(6): 2751-2777, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35755285
17.
Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist).
AAPS J
; 24(6): 99, 2022 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36123502
18.
Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper.
Mol Ther Methods Clin Dev
; 26: 471-494, 2022 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36092368
19.
Inhibition of hepatic organic anion-transporting polypeptide by RNA interference in sandwich-cultured human hepatocytes: an in vitro model to assess transporter-mediated drug-drug interactions.
Drug Metab Dispos
; 38(9): 1612-22, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516252
20.
A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug-Drug Interactions of Bortezomib.
AAPS J
; 22(3): 66, 2020 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32291610