Detalhe da pesquisa
1.
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements.
Chem Res Toxicol
; 36(2): 243-250, 2023 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36705520
2.
Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer.
Hepatology
; 74(1): 264-280, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33462832
3.
Developing urinary pyrrole-amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human.
Arch Toxicol
; 95(10): 3191-3204, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34390356
4.
1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP)-Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA.
Chem Res Toxicol
; 33(8): 2139-2146, 2020 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32588618
5.
1-Formyl-7-hydroxy-6,7-dihydro-5 H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids.
Chem Res Toxicol
; 32(6): 1193-1203, 2019 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31120748
6.
Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation.
Chem Res Toxicol
; 31(7): 619-628, 2018 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29855181
7.
Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned with Heliotropium europaeum.
Chem Res Toxicol
; 30(3): 851-858, 2017 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28125883
8.
7-Glutathione-pyrrole and 7-cysteine-pyrrole are potential carcinogenic metabolites of pyrrolizidine alkaloids.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 35(2): 69-83, 2017 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28418776
9.
The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice.
Arch Toxicol
; 91(2): 949-965, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27125825
10.
Correction to "1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids".
Chem Res Toxicol
; 34(3): 929, 2021 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33646757
11.
Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure.
Chem Res Toxicol
; 29(8): 1282-92, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27388689
12.
7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 34(1): 57-76, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26761716
13.
7-glutathione pyrrole adduct: a potential DNA reactive metabolite of pyrrolizidine alkaloids.
Chem Res Toxicol
; 28(4): 615-20, 2015 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25768656
14.
UVA photoirradiation of benzo[a]pyrene metabolites: induction of cytotoxicity, reactive oxygen species, and lipid peroxidation.
Toxicol Ind Health
; 31(10): 898-910, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23552265
15.
Reaction of dehydropyrrolizidine alkaloids with valine and hemoglobin.
Chem Res Toxicol
; 27(10): 1720-31, 2014 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25211425
16.
Enzyme-like activity of nanomaterials.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 32(2): 186-211, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24875443
17.
Metabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human HaCaT keratinocytes.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 32(4): 362-84, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25436474
18.
Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity.
Chem Res Toxicol
; 26(9): 1384-96, 2013 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937665
19.
Phototoxicity of herbal plants and herbal products.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 31(3): 213-55, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24024520
20.
Phototoxicity of zinc oxide nanoparticles in HaCaT keratinocytes-generation of oxidative DNA damage during UVA and visible light irradiation.
J Nanosci Nanotechnol
; 13(6): 3880-8, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23862422