Detalhe da pesquisa
1.
Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway.
Acta Pharmacol Sin
; 44(2): 308-320, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-35948752
2.
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Acta Pharmacol Sin
; 44(10): 2065-2074, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225845
3.
Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.
Bioorg Med Chem Lett
; 43: 128051, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33887441
4.
Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors.
Bioorg Med Chem Lett
; 30(8): 127036, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32088129
5.
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.
Bioorg Med Chem Lett
; 29(9): 1090-1093, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30833108
6.
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.
Bioorg Med Chem Lett
; 29(8): 1012-1018, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30792039
7.
A Short Half-Life αIIbß3 Antagonist ANTP266 Reduces Thrombus Formation.
Int J Mol Sci
; 19(8)2018 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30082659
8.
Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors.
Bioorg Med Chem Lett
; 26(3): 1068-1072, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26725027
9.
A tryptophan derivative TD-26 attenuates thrombus formation by inhibiting both PI3K/Akt signaling and binding of fibrinogen to integrin αIIbß3.
Biochem Biophys Res Commun
; 465(3): 516-22, 2015 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26278818
10.
Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation.
Bioorg Med Chem Lett
; 25(20): 4557-61, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26342868
11.
LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa.
J Pharmacol Sci
; 127(4): 462-6, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25913760
12.
T5S1607 identified as a antibacterial FtsZ inhibitorï¼Virtual screening combined with bioactivity evaluation for the drug discovery.
Comput Biol Chem
; 108: 108006, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38142532
13.
Discovery of Polo-like Kinase 4 Inhibitors for the Treatment of Cancer: A Mini Patent Review.
Mini Rev Med Chem
; 23(1): 67-79, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-35657046
14.
Thiazole-based analogues as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation.
Eur J Med Chem
; 259: 115689, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37542993
15.
Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives.
J Med Chem
; 66(8): 5332-5363, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37037122
16.
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
J Med Chem
; 65(9): 6356-6389, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35235745
17.
Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors.
J Med Chem
; 65(5): 4318-4334, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35220720
18.
Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases.
J Med Chem
; 64(3): 1283-1345, 2021 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33481605
19.
Zinc enzymes in medicinal chemistry.
Eur J Med Chem
; 226: 113877, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34624823
20.
Discovery and development of plasma kallikrein inhibitors for multiple diseases.
Eur J Med Chem
; 190: 112137, 2020 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32066009