1.
Bioorg Med Chem
; 11(20): 4315-23, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-13129567
RESUMO
The evolution of 2, a C-4-methylcarbonate analogue of paclitaxel with minimal oral bioavailability and oral efficacy, into its C-3'-t-butyl-3'-N-t-butyloxycarbonyl analogue (15i), a novel taxane with oral efficacy in preclinical models that is comparable to iv administered paclitaxel, is described.