Pesquisa | BVS Integralidade em Saúde

1.

Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.

Blaeschke, Franziska; Chen, Yan Yi; Apathy, Ryan; Daniel, Bence; Chen, Andy Y; Chen, Peixin Amy; Sandor, Katalin; Zhang, Wenxi; Li, Zhongmei; Mowery, Cody T; Yamamoto, Tori N; Nyberg, William A; To, Angela; Yu, Ruby; Bueno, Raymund; Kim, Min Cheol; Schmidt, Ralf; Goodman, Daniel B; Feuchtinger, Tobias; Eyquem, Justin; Jimmie Ye, Chun; Carnevale, Julia; Satpathy, Ansuman T; Shifrut, Eric; Roth, Theodore L; Marson, Alexander.

Cell ; 186(19): 4216-4234.e33, 2023 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-37714135

2.

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies.

Roth, Theodore L; Li, P Jonathan; Blaeschke, Franziska; Nies, Jasper F; Apathy, Ryan; Mowery, Cody; Yu, Ruby; Nguyen, Michelle L T; Lee, Youjin; Truong, Anna; Hiatt, Joseph; Wu, David; Nguyen, David N; Goodman, Daniel; Bluestone, Jeffrey A; Ye, Chun Jimmie; Roybal, Kole; Shifrut, Eric; Marson, Alexander.

Cell ; 181(3): 728-744.e21, 2020 04 30.

Artigo em Inglês | MEDLINE | ID: mdl-32302591

3.

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.

Schumann, Kathrin; Raju, Siddharth S; Lauber, Michael; Kolb, Saskia; Shifrut, Eric; Cortez, Jessica T; Skartsis, Nikolaos; Nguyen, Vinh Q; Woo, Jonathan M; Roth, Theodore L; Yu, Ruby; Nguyen, Michelle L T; Simeonov, Dimitre R; Nguyen, David N; Targ, Sasha; Gate, Rachel E; Tang, Qizhi; Bluestone, Jeffrey A; Spitzer, Matthew H; Ye, Chun Jimmie; Marson, Alexander.

Nat Immunol ; 21(11): 1456-1466, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32989329

4.

CSR-1 Slices a Balance.

Yu, Ruby; Moazed, Danesh.

Cell ; 165(2): 267-9, 2016 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-27058659

5.

Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.

Yu, Ruby; Wang, Xiaoyi; Moazed, Danesh.

Nature ; 558(7711): 615-619, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29925950

6.

Reprogramming human T cell function and specificity with non-viral genome targeting.

Roth, Theodore L; Puig-Saus, Cristina; Yu, Ruby; Shifrut, Eric; Carnevale, Julia; Li, P Jonathan; Hiatt, Joseph; Saco, Justin; Krystofinski, Paige; Li, Han; Tobin, Victoria; Nguyen, David N; Lee, Michael R; Putnam, Amy L; Ferris, Andrea L; Chen, Jeff W; Schickel, Jean-Nicolas; Pellerin, Laurence; Carmody, David; Alkorta-Aranburu, Gorka; Del Gaudio, Daniela; Matsumoto, Hiroyuki; Morell, Montse; Mao, Ying; Cho, Min; Quadros, Rolen M; Gurumurthy, Channabasavaiah B; Smith, Baz; Haugwitz, Michael; Hughes, Stephen H; Weissman, Jonathan S; Schumann, Kathrin; Esensten, Jonathan H; May, Andrew P; Ashworth, Alan; Kupfer, Gary M; Greeley, Siri Atma W; Bacchetta, Rosa; Meffre, Eric; Roncarolo, Maria Grazia; Romberg, Neil; Herold, Kevan C; Ribas, Antoni; Leonetti, Manuel D; Marson, Alexander.

Nature ; 559(7714): 405-409, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29995861

7.

The Effect of Social Isolation on Sarcopenia: A Longitudinal Study among the Middle-Aged and Older Population in China.

Hu, Peipei; Zhang, Dexing; Wong, Samuel Yeung Shan; Woo, Jean; Yu, Ruby; Yip, Benjamin Hon Kei; Poon, Paul Kwok Ming.

Gerontology ; 69(6): 748-756, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-36720206

8.

Determinants of heterochromatic siRNA biogenesis and function.

Yu, Ruby; Jih, Gloria; Iglesias, Nahid; Moazed, Danesh.

Mol Cell ; 53(2): 262-76, 2014 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-24374313

9.

Effects of reversible cognitive frailty on disability, quality of life, depression, and hospitalization: a prospective cohort study.

Wang, Wenyu; Si, Huaxin; Yu, Ruby; Qiao, Xiaoxia; Jin, Yaru; Ji, Lili; Liu, Qinqin; Bian, Yanhui; Yu, Jiaqi; Wang, Cuili.

Aging Ment Health ; 26(10): 2031-2038, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-34889147

10.

Effects of social support on frailty trajectory classes among community-dwelling older adults: The mediating role of depressive symptoms and physical activity.

Jin, Yaru; Yu, Ruby; Si, Huaxin; Bian, Yanhui; Qiao, Xiaoxia; Ji, Lili; Liu, Qinqin; Wang, Wenyu; Yu, Jiaqi; Li, Yanyan; Wang, Cuili.

Geriatr Nurs ; 45: 39-46, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35303526

11.

Social gradient of self-rated health in older people-the moderating/mediating role of sense of community.

Lai, Eric T C; Yu, Ruby; Woo, Jean.

Age Ageing ; 50(4): 1283-1289, 2021 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-33454753

12.

Effect of an integrated care model for pre-frail and frail older people living in community.

Yu, Ruby; Tong, Cecilia; Woo, Jean.

Age Ageing ; 49(6): 1048-1055, 2020 10 23.

Artigo em Inglês | MEDLINE | ID: mdl-32479591

13.

Is polypharmacy beneficial or detrimental for older adults with cardiometabolic multimorbidity? Pooled analysis of studies from Hong Kong and Europe.

Cheung, Johnny T K; Yu, Ruby; Woo, Jean.

Fam Pract ; 37(6): 793-800, 2020 11 28.

Artigo em Inglês | MEDLINE | ID: mdl-32596732

14.

Perceptions of Neighborhood Environment, Sense of Community, and Self-Rated Health: an Age-Friendly City Project in Hong Kong.

Yu, Ruby; Wong, Moses; Woo, Jean.

J Urban Health ; 96(2): 276-288, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30511137

15.

Trajectories of frailty among Chinese older people in Hong Kong between 2001 and 2012: an age-period-cohort analysis.

Yu, Ruby; Wong, Moses; Chong, K C; Chang, Billy; Lum, C M; Auyeung, T W; Lee, Jenny; Lee, Ruby; Woo, Jean.

Age Ageing ; 47(2): 254-261, 2018 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-29161361

16.

Geriatric syndromes, multimorbidity, and disability overlap and increase healthcare use among older Chinese.

Cheung, Johnny T K; Yu, Ruby; Wu, Zimu; Wong, Samuel Y S; Woo, Jean.

BMC Geriatr ; 18(1): 147, 2018 06 25.

Artigo em Inglês | MEDLINE | ID: mdl-29940868

17.

Editorial: Can artificial intelligence help us overcome challenges in geriatrics?

Tang, Arthur; Ho, Roger; Yu, Ruby; Huynh, Tom; Luong, Stanley; Tam, Wilson; Resnick, Barbara.

Geriatr Nurs ; 52: A1-A2, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37385836

18.

Reduced Frontal Activations at High Working Memory Load in Mild Cognitive Impairment: Near-Infrared Spectroscopy.

Yeung, Michael K; Sze, Sophia L; Woo, Jean; Kwok, Timothy; Shum, David H K; Yu, Ruby; Chan, Agnes S.

Dement Geriatr Cogn Disord ; 42(5-6): 278-296, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27784013

19.

Effects of cognitive reserve on cognitive frailty among older adults: A population-based prospective cohort study.

Li, Yanyan; Yu, Ruby; Si, Huaxin; Liu, Qinqin; Bian, Yanhui; Yu, Jiaqi; Wang, Cuili.

Geriatr Gerontol Int ; 24(4): 398-403, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38475988

20.

Transitions in intrinsic capacity among community-dwelling older people and their associated factors: a multistate modelling analysis.

Yu, Ruby; Lai, Derek; Leung, Grace; Tam, Lok-Yan; Cheng, Clara; Kong, Sara; Tong, Cecilia; Woo, Jean.

J Nutr Health Aging ; 28(7): 100273, 2024 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-38833766

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