Detalhe da pesquisa
1.
D3EGFR: a webserver for deep learning-guided drug sensitivity prediction and drug response information retrieval for EGFR mutation-driven lung cancer.
Brief Bioinform
; 25(3)2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38555474
2.
Exploring the immune evasion of SARS-CoV-2 variant harboring E484K by molecular dynamics simulations.
Brief Bioinform
; 23(1)2022 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34553217
3.
D3AI-CoV: a deep learning platform for predicting drug targets and for virtual screening against COVID-19.
Brief Bioinform
; 23(3)2022 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35443040
4.
Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma.
Haematologica
; 109(4): 1206-1219, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37767568
5.
Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma.
Arch Biochem Biophys
; 754: 109929, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38367794
6.
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity in vitro and in vivo.
Bioorg Med Chem Lett
; 98: 129590, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38092072
7.
Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors.
Bioorg Med Chem Lett
; 107: 129776, 2024 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38692523
8.
D3Rings: A Fast and Accurate Method for Ring System Identification and Deep Generation of Drug-Like Cyclic Compounds.
J Chem Inf Model
; 64(3): 724-736, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38206320
9.
Ligand-based approach for predicting drug targets and for virtual screening against COVID-19.
Brief Bioinform
; 22(2): 1053-1064, 2021 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33461215
10.
The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13-MAPK-YWHAE signaling pathway.
J Transl Med
; 21(1): 858, 2023 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38012658
11.
Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma.
Arch Biochem Biophys
; 747: 109771, 2023 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37776936
12.
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors.
Bioorg Med Chem Lett
; 95: 129435, 2023 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37549850
13.
Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase.
Bioorg Med Chem
; 91: 117413, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37490786
14.
Preferred microenvironments of halogen bonds and hydrogen bonds revealed using statistics and QM/MM calculation studies.
Phys Chem Chem Phys
; 25(26): 17692-17699, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37367726
15.
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment.
Acta Pharmacol Sin
; 44(6): 1122-1134, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36627343
16.
A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway.
Acta Biochim Biophys Sin (Shanghai)
; 55(2): 215-224, 2023 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36815376
17.
Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation.
Acta Biochim Biophys Sin (Shanghai)
; 55(12): 1884-1891, 2023 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38009004
18.
D3PM: a comprehensive database for protein motions ranging from residue to domain.
BMC Bioinformatics
; 23(1): 70, 2022 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164668
19.
Intravitreal injection of EV11, a novel aryl ketone amide, inhibits choroidal neovascularization via AKT/ERK1/2 pathway.
Microvasc Res
; 143: 104401, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35750130
20.
Activation of the chemokine receptor 3 pathway leads to a better response to immune checkpoint inhibitors in patients with metastatic urothelial carcinoma.
Cancer Cell Int
; 22(1): 186, 2022 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35562800