Detalhe da pesquisa
1.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21896751
2.
Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice.
J Pharmacol Exp Ther
; 337(1): 75-82, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21205914
3.
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Drug Metab Dispos
; 38(1): 16-24, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19833845
4.
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
J Med Chem
; 48(18): 5639-43, 2005 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16134929
5.
Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.
J Med Chem
; 46(18): 3778-81, 2003 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12930139
6.
Quantitative relationship between rifampicin exposure and induction of Cyp3a11 in SXR humanized mice: extrapolation to human CYP3A4 induction potential.
Drug Metab Lett
; 2(3): 169-75, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356089
7.
Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile.
Bioorg Med Chem Lett
; 17(11): 3072-6, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17398093
8.
Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.
Bioorg Med Chem Lett
; 17(4): 974-7, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17187980
9.
The discovery of BMS-275183: an orally efficacious novel taxane.
Bioorg Med Chem
; 11(20): 4315-23, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-13129567
10.
Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 13(8): 1419-23, 2003 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12668003