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2.
Nature ; 2024 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-39455832
3.
Nature ; 2024 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-38714902
4.
Nature ; 630(8018): 807-809, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38890516
6.
Nature ; 2024 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-38977931
7.
Nature ; 2024 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-39039230
9.
Nature ; 628(8006): 221-223, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38561407
11.
Nature ; 625(7994): 215-216, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38195876
12.
Nature ; 2024 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-39232226
15.
BMC Med ; 22(1): 212, 2024 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-38807210

RESUMO

BACKGROUND: To examine the effectiveness and safety of a data sharing and comprehensive management platform for institutionalized older patients. METHODS: We applied information technology-supported integrated health service platform to patients who live at long-term care hospitals (LTCHs) and nursing homes (NHs) with cluster randomized controlled study. We enrolled 555 patients aged 65 or older (461 from 7 LTCHs, 94 from 5 NHs). For the intervention group, a tablet-based platform comprising comprehensive geriatric assessment, disease management, potentially inappropriate medication (PIM) management, rehabilitation program, and screening for adverse events and warning alarms were provided for physicians or nurses. The control group was managed with usual care. Co-primary outcomes were (1) control rate of hypertension and diabetes, (2) medication adjustment (PIM prescription rate, proportion of polypharmacy), and (3) combination of potential quality-of-care problems (composite quality indicator) from the interRAI assessment system which assessed after 3-month of intervention. RESULTS: We screened 1119 patients and included 555 patients (control; 289, intervention; 266) for analysis. Patients allocated to the intervention group had better cognitive function and took less medications and PIMs at baseline. The diabetes control rate (OR = 2.61, 95% CI 1.37-4.99, p = 0.0035), discontinuation of PIM (OR = 4.65, 95% CI 2.41-8.97, p < 0.0001), reduction of medication in patients with polypharmacy (OR = 1.98, 95% CI 1.24-3.16, p = 0.0042), and number of PIMs use (ꞵ = - 0.27, p < 0.0001) improved significantly in the intervention group. There was no significant difference in hypertension control rate (OR = 0.54, 95% CI 0.20-1.43, p = 0.2129), proportion of polypharmacy (OR = 1.40, 95% CI 0.75-2.60, p = 0.2863), and improvement of composite quality indicators (ꞵ = 0.03, p = 0.2094). For secondary outcomes, cognitive and motor function, quality of life, and unplanned hospitalization were not different significantly between groups. CONCLUSIONS: The information technology-supported integrated health service effectively reduced PIM use and controlled diabetes among older patients in LTCH or NH without functional decline or increase of healthcare utilization. TRIAL REGISTRATION: Clinical Research Information Service, KCT0004360. Registered on 21 October 2019.


Assuntos
Prestação Integrada de Cuidados de Saúde , Assistência de Longa Duração , Humanos , Idoso , Masculino , Feminino , Idoso de 80 Anos ou mais , Assistência de Longa Duração/métodos , Tecnologia da Informação , Casas de Saúde , Polimedicação
16.
Artigo em Inglês | MEDLINE | ID: mdl-39379678

RESUMO

PURPOSE: Clinical trials are essential to the advancement of cancer care. However, clinical trial knowledge and participation remain critically low among adult patients with cancer. Health information technology (HIT) could play an important role in improving clinical trial knowledge and engagement among cancer survivors. METHODS: We used data from 3,794 adults who completed the 2020 Health Information National Trends Survey, 626 (16.2%) of whom were cancer survivors. We examined the prevalence of HIT use in the study population and by cancer history using chi-squared tests. We used multivariable logistic regression models to examine the impact of HIT use on clinical trial knowledge for cancer survivors and respondents with no cancer history, respectively. RESULTS: Approximately 63.8% of cancer survivors reported having some knowledge of clinical trials. Almost half of the cancer survivors used HIT to communicate with doctors (47.1%) and make health appointments (49.4%), 68.0% used HIT to look up health information online and 42.2% used it to check test results. In the adjusted models, the use of HIT in communicating with doctors [OR 2.79; 95% CI (1.41, 5.54)], looking up health information online [OR 2.84; 95% CI (1.04, 7.77)], and checking test results [OR 2.47; 95% CI (1.12, 5.43)] was associated with having some knowledge of clinical trials. CONCLUSION: HIT use for engaging with the healthcare team and health information gathering is associated with higher clinical trial knowledge in cancer survivors. Given the rapid increase in mobile technology access globally and the increased use of HIT, digital technology can be leveraged to improve clinical trial knowledge and engagement among cancer survivors.

17.
Chemistry ; 30(12): e202303635, 2024 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-38055217

RESUMO

Covalently-linked chromophore-radical systems with their unique optical and magnetic properties are useful for applications in, e. g., quantum information science. To expand the catalog of molecular systems, we synthesized and characterized six novel chromophore-radical and radical-chromophore-radical systems employing derivatives of perylene diimide (PDI) as the chromophore and trityl as the radical. The EPR properties of these compounds were evaluated in solution at cryogenic and room temperatures. In addition, the electron spin-spin coupling in the two bistrityl systems was investigated using DQC measurements. The presented results serve as a basis for further spectroscopic investigations under photoexcitation of the PDI core.

18.
Int J Legal Med ; 138(6): 2583-2585, 2024 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-39014248

RESUMO

Internationally, the quality of death certification is poor although there are multiple efforts underway to improve the process. In England, a new medical certification system has been proposed to improve the quality of data. We surveyed general practitioners (n = 95) across the West Yorkshire area of England to appraise their views regarding whether further possible changes to the death certification system could promote their quality.


Assuntos
Causas de Morte , Atestado de Óbito , Humanos , Inglaterra , País de Gales , Inquéritos e Questionários , Clínicos Gerais , Atitude do Pessoal de Saúde
19.
Nature ; 2023 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-37857883
20.
Nature ; 2023 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-37463997
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