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1.
Acta Anaesthesiol Scand ; 68(2): 247-253, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37876139

RESUMO

BACKGROUND: Patients undergoing caesarean delivery are at risk of developing unintended perioperative hypothermia, defined as a core temperature <36.0°C. Most previous studies of core temperature in caesarean delivery patients have not been conducted with accurate measurements for the complete perioperative period. Therefore, we conducted a prospective observational study to identify the incidence and duration of pre- and post-operative maternal hypothermia with a high accuracy continuous temperature monitoring system. METHODS: Women ≥18 years old presenting for elective caesarean delivery under spinal anaesthesia were invited to participate in the study. The primary outcomes were the incidence and duration of perioperative maternal hypothermia (<36.0°C). Maternal core temperatures were measured with the non-invasive zero-heat-flux thermometer (Bair Hugger Temperature Monitoring System, 3M) throughout the perioperative course. RESULTS: A total of 40 participants were recruited to the study. The incidence of perioperative hypothermia was 32.5%, with a duration of 77 ± 40 min (mean ± standard deviation). The hypothermic patients had similar core temperature as the normothermic patients at baseline preoperatively, but significantly lower temperature at operating room arrival and during the remaining study period. Forty percent of all patients reported thermal discomfort and felt cold on admission to post anaesthesia care unit, whereas 33% had shivering. Neither thermal discomfort nor shivering were associated with hypothermia. CONCLUSION: In the present study almost a third of the women undergoing elective caesarean delivery developed perioperative hypothermia with a core temperature <36.0°C. The mean duration of maternal hypothermia was 77 min, lasting well into the postoperative period for many patients. These data should remind healthcare professionals of the importance of measuring core temperature in all phases of the perioperative setting and to consider optimal warming measures to avoid and treat hypothermia.


Assuntos
Hipotermia , Gravidez , Humanos , Feminino , Adolescente , Hipotermia/epidemiologia , Hipotermia/etiologia , Resultado do Tratamento , Temperatura Corporal , Temperatura Cutânea , Cesárea/efeitos adversos
2.
Sensors (Basel) ; 24(3)2024 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-38339736

RESUMO

Heat flux measurement shows potential for the early detection of infectious growth. Our research is motivated by the possibility of using heat flux sensors for the early detection of infection on aortic vascular grafts by measuring the onset of bacterial growth. Applying heat flux measurement as an infectious marker on implant surfaces is yet to be experimentally explored. We have previously shown the measurement of the exponential growth curve of a bacterial population in a thermally stabilized laboratory environment. In this work, we further explore the limits of the microcalorimetric measurements via heat flux sensors in a microfluidic chip in a thermally fluctuating environment.


Assuntos
Temperatura Alta , Microfluídica , Calorimetria , Próteses e Implantes , Diagnóstico Precoce
3.
Sensors (Basel) ; 24(6)2024 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-38544149

RESUMO

Non-invasive core body temperature (CBT) measurements using temperature and heat-flux have become popular in health, sports, work safety, and general well-being applications. This research aimed to evaluate two commonly used sensor designs: those that combine heat flux and temperature sensors, and those with four temperature sensors. We used analytical methods, particularly uncertainty analysis calculus and Monte Carlo simulations, to analyse measurement accuracy, which depends on the accuracy of the temperature and flux sensors, mechanical construction parameters (such as heat transfer coefficient), ambient air temperature, and CBT values. The results show the relationship between the accuracy of each measurement method variant and various sensor parameters, indicating their suitability for different scenarios. All measurement variants showed unstable behaviour around the point where ambient temperature equals CBT. The ratio of the heat transfer coefficients of the dual-heat flux (DHF) sensor's channels impacts the CBT estimation uncertainty. An analysis of the individual components of uncertainty in CBT estimates reveals that the accuracy of temperature sensors significantly impacts the overall uncertainty of the CBT measurement. We also calculated the theoretical limits of measurement uncertainty, which varied depending on the method variant and could be as low as 0.05 °C.

4.
J Clin Monit Comput ; 38(1): 197-203, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37792140

RESUMO

To identify and prevent perioperative hypothermia, most surgical patients require a non-invasive, accurate, convenient, and continuous core temperature method, especially for patients undergoing major surgery. This study validated the precision and accuracy of a cutaneous zero-heat-flux thermometer and its performance in detecting intraoperative hypothermia. Adults undergoing major non-cardiac surgeries with general anaesthesia were enrolled in the study. Core temperatures were measured with a zero-heat-flux thermometer, infrared tympanic membrane thermometer, and oesophagal monitoring at 15-minute intervals. Taking the average value of temperature measured in the tympanic membrane and oesophagus as a reference, we assessed the agreement using the Bland-Altman analysis and linear regression methods. Sensitivity, specificity, and predictive values of detecting hypothermia were estimated. 103 patients and one thousand sixty-eight sets of paired temperatures were analyzed. The mean difference between zero-heat-flux and the referenced measurements was -0.03 ± 0.25 °C, with 95% limits of agreement (-0.52 °C, 0.47 °C) was narrow, with 94.5% of the differences within 0.5 °C. Lin's concordance correlation coefficient was 0.90 (95%CI 0.89-0.92). The zero-heat-flux thermometry detected hypothermia with a sensitivity of 82% and a specificity of 90%. The zero-heat-flux thermometer is in good agreement with the reference core temperature based on tympanic and oesophagal temperature monitoring in patients undergoing major surgeries, and appears high performance in detecting hypothermia.


Assuntos
Hipotermia , Termometria , Adulto , Humanos , Temperatura Corporal , Temperatura , Temperatura Alta , Monitorização Intraoperatória/métodos , Termômetros , Esôfago
5.
Nano Lett ; 23(21): 10044-10050, 2023 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-37889143

RESUMO

We show that engineering phonon scattering, such as through isotope enrichment and temperature modulation, offers the potential to achieve unconventional radiative heat transfer between two boron arsenide bulks at the nanoscale, which holds promise in applications for nonlinear thermal circuit components. A heat flux regulator is proposed, where the temperature window for stabilized heat flux exhibits a wide tunability through phonon scattering engineering. Additionally, we propose several other nonlinear thermal radiative devices, including a negative differential thermal conductance device, a temperature regulator, and a thermal diode, all benefiting from the design space enabled by isotope and temperature engineering of the phonon linewidth. Our work highlights the capability of temperature and isotope engineering in designing and optimizing nonlinear radiative thermal devices and demonstrates the potential of phonon engineering in thermal radiative transport.

6.
J Environ Manage ; 356: 120740, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38520853

RESUMO

Stomatal conductance (gs) and compensatory water uptake (CWU) are crucial processes in land surface models, as they directly influence the exchange of carbon and water fluxes between terrestrial ecosystems and the atmosphere. In this study, we integrated a new stomatal scheme derived from optimal stomatal theory (Medlyn's gs model), and an empirical CWU scheme into the Common Land Model (CoLM). Assessing the impacts on modeling gross primary productivity (GPP) and latent flux (LE) through observations obtained from eddy covariance (EC) measurements at three forest sites in China. Our results show that replacing the Ball-Berry's gs model (termed BB) with Medlyn's gs model (termed MED) did not bring about significant changes (had neutral impacts) in the performance of CoLM simulations at three forest sites. Considering the climate factors of annual mean precipitation to optimize key fitting parameters in gs exhibited improvement in model simulations. The average coefficient of determination (R2) achieved to 0.65 for GPP and LE at three sites, and the normalized root mean squared error (NRMSE) decreased from 0.83 to 0.77 at those sites. Besides, incorporating CWU into the model improved its performance. The R2 increased to 0.84 and RMSE decreased to 4.84 µmol m-2 s-1 for GPP, and the R2 increased to 0.62 and RMSE decreased to 55.64 W m-2 for LE. Therefore, modifying the model process of both contributed more to enhancing the model simulations than relying solely on one of these functions. Our study highlights that the response of plant functional types (PFTs) to water stress can be effectively represented in gs models when coupled with biochemical capacity to quantify carbon and water fluxes in forest ecosystems or other ecosystems.


Assuntos
Carbono , Ecossistema , Florestas , Plantas , China , Ciclo do Carbono
7.
Plant Cell Environ ; 46(10): 3128-3143, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-36794448

RESUMO

The modulation of the leaf energy budget components to maintain optimal leaf temperature are fundamental aspects of plant functioning and survival. Better understanding these aspects becomes increasingly important under a drying and warming climate when cooling through evapotranspiration (E) is suppressed. Combining novel measurements and theoretical estimates, we obtained unusually comprehensive twig-scale leaf energy budgets under extreme field conditions in droughted (suppressed E) and non-droughted (enhanced E) plots of a semi-arid pine forest. Under the same high mid-summer radiative load, leaf cooling shifted from relying on nearly equal contributions of sensible (H) and latent (LE) energy fluxes in non-droughted trees to relying almost exclusively on H in droughted ones, with no change in leaf temperature. Relying on our detailed leaf energy budget, we could demonstrate that this is due to a 2× reduction in leaf aerodynamic resistance. This capability for LE-to-H shift in leaves of mature Aleppo pine trees under droughted field conditions without increasing leaf temperature is likely a critical factor in the resilience and relatively high productivity of this important Mediterranean tree species under drying conditions.


Assuntos
Clima , Secas , Estações do Ano , Temperatura , Árvores , Folhas de Planta
8.
Philos Trans A Math Phys Eng Sci ; 381(2249): 20220067, 2023 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-37150204

RESUMO

Progress in understanding Southern Ocean heat exchange and wind forcing is discussed and new results presented. These include a metric of the zonal asymmetry between surface ocean heat gain in the Atlantic/Indian sector and heat loss in the Pacific sector. The asymmetry arises from an intersector variation in the humidity gradient between the sea surface and near-surface atmosphere. This gradient increases by 60% in the Pacific sector enabling a 20 Wm-2 stronger latent heat loss compared with the Atlantic/Indian sector. The new metric is used for intercomparison of atmospheric reanalyses and CMIP6 climate simulations. CMIP6 has weaker Atlantic/Indian sector heat gain compared with the reanalyses primarily due to Indian Ocean sector differences. The potential for surface flux buoys to provide an observation-based counterpart to the asymmetry metric is explored. Over the past decade, flux buoys have been deployed at two sites (south of Tasmania and upstream of Drake Passage). The data record provided by these moorings is assessed and an argument developed for a third buoy to sample the Atlantic/Indian sector of the asymmetry metric. To close, we assess evidence that the main westerly wind belt has strengthened and moved southward in recent decades using the ERA5 reanalysis. This article is part of a discussion meeting issue 'Heat and carbon uptake in the Southern Ocean: the state of the art and future priorities'.

9.
Proc Natl Acad Sci U S A ; 117(41): 25378-25385, 2020 10 13.
Artigo em Inglês | MEDLINE | ID: mdl-32958634

RESUMO

Our study reveals a hitherto overlooked ecological threat of climate change. Studies of warming events in the ocean have typically focused on the events' maximum temperature and duration as the cause of devastating disturbances in coral reefs, kelp forests, and rocky shores. In this study, however, we found that the rate of onset (Ronset), rather than the peak, was the likely trigger of mass mortality of coral reef fishes in the Red Sea. Following a steep rise in water temperature (4.2 °C in 2.5 d), thermally stressed fish belonging to dozens of species became fatally infected by Streptococcus iniae Piscivores and benthivores were disproportionately impacted whereas zooplanktivores were spared. Mortality rates peaked 2 wk later, coinciding with a second warming event with extreme Ronset The epizootic lasted ∼2 mo, extending beyond the warming events through the consumption of pathogen-laden carcasses by uninfected fish. The warming was widespread, with an evident decline in wind speed, barometric pressure, and latent heat flux. A reassessment of past reports suggests that steep Ronset was also the probable trigger of mass mortalities of wild fish elsewhere. If the ongoing increase in the frequency and intensity of marine heat waves is associated with a corresponding increase in the frequency of extreme Ronset, calamities inflicted on coral reefs by the warming oceans may extend far beyond coral bleaching.


Assuntos
Mudança Climática , Recifes de Corais , Doenças dos Peixes/mortalidade , Peixes , Infecções Estreptocócicas/veterinária , Animais , Antozoários , Surtos de Doenças/veterinária , Doenças dos Peixes/microbiologia , Resposta ao Choque Térmico , Oceano Índico , Infecções Estreptocócicas/microbiologia , Infecções Estreptocócicas/mortalidade , Streptococcus iniae/isolamento & purificação , Fatores de Tempo
10.
Int J Biometeorol ; 67(8): 1345-1352, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37365382

RESUMO

When a pandemic such as that caused by the novel coronavirus disease termed COVID-19 emerges, it is recommended to wear a mask when in public situations, with information regarding the impact on thermoregulation essential, especially during exercise or hard physical labor. The present study investigated changes in core body temperature (CBT) while wearing a surgical mask (SM) during exercise (TCBT) using a non-invasive zero-heat-flux (ZHF) thermometer. Nine young adult females performed ergometer exercise for 30 min at 60 W with (mask group) and without (control) a SM under a non-hot condition, shown by wet bulb globe temperature (WBGT) findings. TCBT, mean skin temperature (TMST), heart rate (HR), and humidity in the perioral region of the face (%RH) were determined. Each of those markers showed increased values during exercise, with the increases in TCBT, HR, and %RH, but not TMST, during exercise found to be significantly greater in the mask group. HR reserve (%HRR), derived as load intensity during exercise, was also significantly higher in the mask group. Each subject completed all of the experimental protocols without noting pain or discomfort. These results suggest that wearing a SM while performing mild exercise contributes to increased TCBT associated with increased exercise intensity, expressed as %HRR in a non-heated condition. Furthermore, the ZHF thermometer was shown to be safe and is considered useful for conducting such studies. Additional examinations will be necessary to examine gender and age group differences, as well as the use of different exercise methods and intensity and ambient conditions.


Assuntos
Temperatura Corporal , COVID-19 , Humanos , Adulto Jovem , Feminino , Temperatura Alta , Termômetros , Exercício Físico/fisiologia , Regulação da Temperatura Corporal/fisiologia
11.
Adv Space Res ; 71(1): 1017-1033, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36186546

RESUMO

COVID-19 pandemic has had a major impact on our society, environment and public health, in both positive and negative ways. The main aim of this study is to monitor the effect of COVID-19 pandemic lockdowns on urban cooling. To do so, satellite images of Landsat 8 for Milan and Rome in Italy, and Wuhan in China were used to look at pre-lockdown and during the lockdown. First, the surface biophysical characteristics for the pre-lockdown and within-lockdown dates of COVID-19 were calculated. Then, the land surface temperature (LST) retrieved from Landsat thermal data was normalized based on cold pixels LST and statistical parameters of normalized LST (NLST) were calculated. Thereafter, the correlation coefficient (r) between the NLST and index-based built-up index (IBI) was estimated. Finally, the surface urban heat island intensity (SUHII) of different cities on the lockdown and pre-lockdown periods was compared with each other. The mean NLST of built-up lands in Milan (from 7.71 °C to 2.32 °C), Rome (from 5.05 °C to 3.54 °C) and Wuhan (from 3.57 °C to 1.77 °C) decreased during the lockdown dates compared to pre-lockdown dates. The r (absolute value) between NLST and IBI for Milan, Rome and Wuhan decreased from 0.43, 0.41 and 0.16 in the pre-lockdown dates to 0.25, 0.24, and 0.12 during lockdown dates respectively, which shows a large decrease for all cities. Analysis of SUHI for these cities showed that SUHII during the lockdown dates compared to pre-lockdown dates decreased by 0.89 °C, 1.78 °C, and 1.07 °C respectively. The results indicated a high and substantial impact of anthropogenic activities and anthropogenic heat flux (AHF) on the SUHI due to the substantial reduction of huge anthropogenic pressure in cities. Our conclusions draw attention to the contribution of COVID-19 lockdowns (reducing the anthropogenic activities) to creating cooler cities.

12.
Sensors (Basel) ; 23(17)2023 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-37688066

RESUMO

The escalation of anthropogenic heat emissions poses a significant threat to the urban thermal environment as cities continue to develop. However, the impact of urban spatial form on anthropogenic heat flux (AHF) in different urban functional zones (UFZ) has received limited attention. In this study, we employed the energy inventory method and remotely sensed technology to estimate AHF in Beijing's central area and utilized the random forest algorithm for UFZ classification. Subsequently, linear fitting models were developed to analyze the relationship between AHF and urban spatial form indicators across diverse UFZ. The results show that the overall accuracy of the classification was determined to be 87.2%, with a Kappa coefficient of 0.8377, indicating a high level of agreement with the actual situation. The business/commercial zone exhibited the highest average AHF value of 33.13 W m-2 and the maximum AHF value of 338.07 W m-2 among the six land functional zones, indicating that business and commercial areas are the primary sources of anthropogenic heat emissions. The findings reveal substantial variations in the influence of urban spatial form on AHF across different UFZ. Consequently, distinct spatial form control requirements and tailored design strategies are essential for each UFZ. This research highlights the significance of considering urban spatial form in mitigating anthropogenic heat emissions and emphasizes the need for customized planning and renewal approaches in diverse UFZ.

13.
Sensors (Basel) ; 23(4)2023 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-36850568

RESUMO

Monitoring core body temperature (CBT) allows observation of heat stress and thermal comfort in various environments. By introducing a Peltier element, we improved the zero-heat-flux core body thermometer for hot environments. In this study, we performed a theoretical analysis, designed a prototype probe, and evaluated its performance through simulator experiments with human subjects. The finite element analysis shows that our design can reduce the influence of external temperature variations by as much as 1%. In the simulator experiment, the prototype probe could measure deep temperatures within an error of less than 0.1 °C, regardless of outside temperature change. In the ergometer experiment with four subjects, the average difference between the prototype probe and a commercial zero-heat-flux probe was +0.1 °C, with a 95% LOA of -0.23 °C to +0.21 °C. In the dome sauna test, the results measured in six of the seven subjects exhibited the same trend as the reference temperature. These results show that the newly developed probe with the Peltier module can measure CBT accurately, even when the ambient temperature is higher than CBT up to 42 °C.


Assuntos
Temperatura Corporal , Termômetros , Humanos , Análise de Elementos Finitos
14.
J Clin Monit Comput ; 37(5): 1153-1159, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-36879085

RESUMO

Zero-heat-flux core temperature measurements on the forehead (ZHF-forehead) show acceptable agreement with invasive core temperature measurements but are not always possible in general anesthesia. However, ZHF measurements over the carotid artery (ZHF-neck) have been shown reliable in cardiac surgery. We investigated these in non-cardiac surgery. In 99 craniotomy patients, we assessed agreement of ZHF-forehead and ZHF-neck (3M™ Bair Hugger™) with esophageal temperatures. We applied Bland-Altman analysis and calculated mean absolute differences (difference index) and proportion of differences within ± 0.5 °C (percentage index) during entire anesthesia and before and after esophageal temperature nadir. In Bland-Altman analysis [mean (limits of agreement)], agreement with esophageal temperature during entire anesthesia was 0.1 (-0.7 to +0.8) °C (ZHF-neck) and 0.0 (-0.8 to +0.8) °C (ZHF-forehead), and, after core temperature nadir, 0.1 (-0.5 to +0.7) °C and 0.1 (-0.6 to +0.8) °C, respectively. In difference index [median (interquartile range)], ZHF-neck and ZHF-forehead performed equally during entire anesthesia [ZHF-neck: 0.2 (0.1-0.3) °C vs ZHF-forehead: 0.2 (0.2-0.4) °C], and after core temperature nadir [0.2 (0.1-0.3) °C vs 0.2 (0.1-0.3) °C, respectively; all p > 0.017 after Bonferroni correction]. In percentage index [median (interquartile range)], both ZHF-neck [100 (92-100) %] and ZHF-forehead [100 (92-100) %] scored almost 100% after esophageal nadir. ZHF-neck measures core temperature as reliably as ZHF-forehead in non-cardiac surgery. ZHF-neck is an alternative to ZHF-forehead if the latter cannot be applied.


Assuntos
Temperatura Alta , Termometria , Humanos , Temperatura , Temperatura Corporal , Artéria Carótida Primitiva , Anestesia Geral , Craniotomia , Termômetros
15.
J Clin Monit Comput ; 37(6): 1619-1626, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37436599

RESUMO

PURPOSE: Temperature monitoring in the perioperative setting often represents a compromise between accuracy, invasiveness of probe placement, and patient comfort. Transcutaneous sensors using the Zero-Heat-Flux (ZHF) and Double-Sensor (DS) technology have been developed and evaluated in a variety of clinical settings. The present study is the first to compare the performance of both sensors simultaneously with temperature measured by a Swan-Ganz catheter (PAC) in patients admitted to the intensive care unit (ICU) after cardiac surgery. METHODS: In this monocentric prospective observational study patients were postoperatively transferred to the ICU and both sensors were placed on the patients' foreheads. Core body temperature measured by intraoperatively placed PAC served as gold standard. Measurements were recorded at 5-minute intervals and up to 40 data sets per patient were recorded. Bland and Altman's method for repeated measurements was used to analyse agreement. Subgroup analyses for gender, body-mass-index, core temperature, airway status and different time intervals were performed. Lin's concordance correlation coefficient (LCCC) was calculated, as well as sensitivity and specificity for detecting hyperthermia (≥ 38 °C) and hypothermia (< 36 °C). RESULTS: Over a period of six month, we collected 1600 sets of DS, ZHF, and PAC measurements, from a total of 40 patients. Bland-Altman analysis revealed a mean bias of -0.82 ± 1.27 °C (average ± 95% Limits-of-Agreement (LoA)) and - 0.54 ± 1.14 °C for DS and ZHF, respectively. The LCCC was 0.5 (DS) and 0.63 (ZHF). Mean bias was significantly higher in hyperthermic and hypothermic patients. Sensitivity and specificity were 0.12 / 0.99 (DS) and 0.35 / 1.0 (ZHF) for hyperthermia and 0.95 / 0.72 (DS) and 1.0 / 0.85 (ZHF) for hypothermia. CONCLUSION: Core temperature was generally underestimated by the non-invasive approaches. In our study, ZHF outperformed DS. In terms of agreement, results for both sensors were outside the range that is considered clinically acceptable. Nevertheless, both sensors might be adequate to detect postoperative hypothermia reliably when more invasive methods are not available or appropriate. TRIAL REGISTRATION: German Register of Clinical Trials (DRKS-ID: DRKS00027003), retrospectively registered 10/28/2021.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Hipotermia , Humanos , Temperatura Corporal , Hipotermia/diagnóstico , Unidades de Terapia Intensiva , Termômetros , Estudos Prospectivos
16.
Math Mech Solids ; 28(8): 1790-1797, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37404471

RESUMO

We use complex variable techniques to study the decoupled two-dimensional steady-state heat conduction and thermoelastic problems associated with an elliptical elastic inhomogeneity perfectly bonded to an infinite matrix subjected to a nonuniform heat flux at infinity. Specifically, the nonuniform remote heat flux takes the form of a linear distribution. It is found that the internal temperature and thermal stresses inside the elliptical inhomogeneity are quadratic functions of the two in-plane coordinates. Explicit closed-form expressions of the analytic functions characterizing the temperature and thermoelastic field in the matrix are derived.

17.
Cell Commun Signal ; 20(1): 66, 2022 05 18.
Artigo em Inglês | MEDLINE | ID: mdl-35585601

RESUMO

Notch signalling pathway plays a key role in metazoan biology by contributing to resolution of binary decisions in the life cycle of cells during development. Outcomes such as proliferation/differentiation dichotomy are resolved by transcriptional remodelling that follows a switch from Notchon to Notchoff state, characterised by dissociation of Notch intracellular domain (NICD) from DNA-bound RBPJ. Here we provide evidence that transitioning to the Notchoff state is regulated by heat flux, a phenomenon that aligns resolution of fate dichotomies to mitochondrial activity. A combination of phylogenetic analysis and computational biochemistry was utilised to disclose structural adaptations of Notch1 ankyrin domain that enabled function as a sensor of heat flux. We then employed DNA-based micro-thermography to measure heat flux during brain development, followed by analysis in vitro of the temperature-dependent behaviour of Notch1 in mouse neural progenitor cells. The structural capacity of NICD to operate as a thermodynamic sensor in metazoans stems from characteristic enrichment of charged acidic amino acids in ß-hairpins of the ankyrin domain that amplify destabilising inter-residue electrostatic interactions and render the domain thermolabile. The instability emerges upon mitochondrial activity which raises the perinuclear and nuclear temperatures to 50 °C and 39 °C, respectively, leading to destabilization of Notch1 transcriptional complex and transitioning to the Notchoff state. Notch1 functions a metazoan thermodynamic sensor that is switched on by intercellular contacts, inputs heat flux as a proxy for mitochondrial activity in the Notchon state via the ankyrin domain and is eventually switched off in a temperature-dependent manner. Video abstract.


Assuntos
Anquirinas , Células-Tronco Neurais , Receptores Notch , Animais , Anquirinas/química , Anquirinas/metabolismo , Camundongos , Células-Tronco Neurais/química , Células-Tronco Neurais/metabolismo , Filogenia , Domínios Proteicos , Receptores Notch/química , Receptores Notch/metabolismo , Transdução de Sinais , Termodinâmica
18.
Geophys Res Lett ; 49(7): e2021GL096968, 2022 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-35865656

RESUMO

Surface latent heat fluxes help maintain tropical intraseasonal precipitation. We develop a latent heat flux diagnostic that depicts how latent heat fluxes vary with the near-surface specific humidity vertical gradient (Δq) and surface wind speed (|V|). Compared to fluxes estimated from |V| and Δq measured at tropical moorings and the Coupled Ocean Atmosphere Response Experiment 3.0 (COARE3.0) algorithm, tropical latent heat fluxes in the National Center for Atmospheric Research CEMS2 and Department of Energy E3SMv1 models are significantly overestimated at |V| and Δq extrema. Madden-Julian oscillation (MJO) sensitivity to surface flux algorithm is tested with offline and inline flux corrections. The offline correction adjusts model output fluxes toward mooring-estimated fluxes; the inline correction replaces the original bulk flux algorithm with the COARE3.0 algorithm in atmosphere-only simulations of each model. Both corrections indicate reduced latent heat flux feedback to intraseasonal precipitation, in better agreement with observations, suggesting that model-simulated fluxes are overly supportive for maintaining MJO convection.

19.
Sci Technol Adv Mater ; 23(1): 767-782, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36386550

RESUMO

Transverse thermoelectric generation using magnetic materials is essential to develop active thermal engineering technologies, for which the improvements of not only the thermoelectric output but also applicability and versatility are required. In this study, using combinatorial material science and lock-in thermography technique, we have systematically investigated the transverse thermoelectric performance of Sm-Co-based alloy films. The high-throughput material investigation revealed the best Sm-Co-based alloys with the large anomalous Nernst effect (ANE) as well as the anomalous Ettingshausen effect (AEE). In addition to ANE/AEE, we discovered unique and superior material properties in these alloys: the amorphous structure, low thermal conductivity, and large in-plane coercivity and remanent magnetization. These properties make it advantageous over conventional materials to realize heat flux sensing applications based on ANE, as our Sm-Co-based films can generate thermoelectric output without an external magnetic field. Importantly, the amorphous nature enables the fabrication of these films on various substrates including flexible sheets, making the large-scale and low-cost manufacturing easier. Our demonstration will provide a pathway to develop flexible transverse thermoelectric devices for smart thermal management.

20.
Sensors (Basel) ; 22(19)2022 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-36236358

RESUMO

The present study exposes an economical and easy-to-use system to assess the heat transfer in building envelopes by determining the U-value. Nowadays these systems require long wires and a host to collect and process the data. In this work, a multi-point system for simultaneous heat flux measurement has been proposed. The aim is to reduce the long measurement time and the cost of thermal isolation evaluations in large buildings. The system proposed consists of a low-cost 3D-printed heat flux sensor integrated with a LoRa transceiver and two temperature sensors. The heat flux (HF) sensor was compared and calibrated with a commercial HF sensor from the Fluxteq brand.


Assuntos
Temperatura Alta , Coleta de Dados
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