Extended analysis of solid cancer incidence among nuclear industry workers in the UK 1955-2011: comparison of workers first hired in earlier and later periods.

To address points arising from the recent study of nuclear workers in the USA and the International Nuclear Workers Study (INWORKS), concerning the difference in solid cancer risk estimates between those first hired in earlier and later calendar years, subsidiary analyses were conducted on a cohort of 172 452 workers in the National Registry for Radiation Workers (NRRW) from the UK. A total of 18 310 incident first primary solid cancer cases were registered in the period from 1955 until 2011 in the NRRW cohort and workers accrued 5.25 million person-years of follow-up. Incidences rates of all solid cancers combined, lung cancer and solid cancer excluding lung cancer were examined in terms of external radiation doses in the full cohort and in a sub-cohort of workers who had no record of internal exposure monitoring and were defined by the periods of first hire before and after the beginning of the years 1960, 1965 and 1970. All analyses were carried out using Poisson Regression. These analyses demonstrated that only for lung cancer between the pre-1965 and post-1964 periods is there strong evidence for a difference in the risks using the NRRW full cohort. In the other calendar period breakdowns and for the other cancer groups, there is no clear evidence of differences in the risks. The NRRW estimation of risks between recent and early workers is not generally consistent with the US workers cohort or the INWORKS evaluations that later hired workers are at much higher solid cancer risk than earlier hired workers, although INWORKS contains a significant part of the latest updated NRRW cohort as well as the US data. The conclusion that the INWORKS and US study data demonstrate a real difference in excess solid cancer risk from external radiation exposure between earlier and later workers is premature. The results presented here should also be treated with caution because of the limited corroborating evidence from other published studies. Information on internal doses, neutron doses as well as non-radiation factors such as smoking and asbestos exposure would be needed to make definitive inferences.

Bernardino Ramazzini's De Morbis Artificum Diatriba on Workers' Health-the Birth of a New Discipline.

This paper provides a picture of the observations made over three hundred years ago by Bernardino Ramazzini (1633-1714) in light of current topical issues ranging from health problems related to work and lifestyle habits to the current burdensome COVID-19 pandemic. The main aspects of his work consist of descriptions of disorders linked to environmental risks, suggestions for measures for risk protection, and recommendations for healthy living. This paper focuses on Ramazzini's most relevant achievements by (1) analyzing the episodes that stimulated the composition of his main work and highlighting some observations on which current epidemiological and toxicological studies are based; (2) reviewing his work showing not only the systematic descriptions of work-related illnesses caused by occupational factors but also his sound etiological and physiopathological contributions to the field of occupational lung diseases, breast cancer, and environmental disorders; and (3) remarking on his main observations in the fields of risk prevention and health promotion, also in the light of some highly topical issues related to unhealthy lifestyle habits and the COVID-19 pandemic.

The health of restaurant work: A historical and social context to the occupational health of food service.

The United States currently has over one million restaurants, making food service one of the largest workforces and industry sectors in the nation's economy. Historically, concern for the health of early restaurant workers was tied largely to the hygiene of the food and thus the wellbeing of the customer rather than the individuals preparing the food. The landscape of occupational illness and injury that resulted is fraught with some of the starkest health disparities in wages, discrimination, benefits, injuries, and illness seen among US laborers. These disparities have consistently been associated with social class and economic position. Conditions identified during the early years of restaurant work, before the introduction of occupational safety and health protections, persist today largely due to tipped wages, dependence on customer discretion, and the management structure. Research and intervention efforts to control occupational health hazards should be directed toward the socioeconomic and structural roots of health problems among food service workers in the United States. Such efforts have important implications for enhancing worker protections, improving wages, and restructuring working conditions for restaurant and food service workers. They also suggest opportunities for occupational health practitioners and researchers to contribute to system-level change analysis to address centuries-old occupational health challenges still facing one of the largest sectors of workers in the country.

Analysis of Occupational Safety and Health Administration (OSHA) noise standard violations over 50 years: 1972 to 2019.

INTRODUCTION: Noise exposure has long been an occupational health concern and has been an important area of focus of the Occupational Safety and Health Administration (OSHA) since its founding. Nevertheless, it remains unclear what effects OSHA's noise standards have had on employer efforts to reduce risks. Consequently, a review of OSHA noise standard violations was performed to clarify the violation trends between 1972 and 2019. METHODS: Using the OSHA Information System, researchers identified 119 305 violations involving four noise standards between 1972 and 2019: 29 CFR 1910.95, occupational noise exposure in general industry; 1926.52, occupational noise exposure in construction; 1926.101, hearing protection in construction, and 1904.10, recording criteria for cases involving occupational hearing loss. Violation frequencies of noise standard subparagraphs and relationships to factors such as industry differences were analyzed using descriptive statistics and t tests. RESULTS: The most commonly violated noise standard was 1910.95 in manufacturing. Such violations rose between 1972 and 1985 and then declined steadily. Whether in general industry or construction, four noise standards were most-frequently cited: lack of feasible administrative or engineering controls (1910.95[b] and 1926.52[d]) and inadequate hearing conservation program (1910.95[c] and 1926.52[b]). These violations were more highly penalized (mean = $1036.50) than other subparagraph violations (mean = $915.80). Programmed and unprogrammed inspections generated similar violation quantities except between 1980 and 1985, when programmed inspections exhibited a sharp spike in violations. CONCLUSION: The study identified trends in OSHA noise standard violations and possible explanations for those trends. The study findings can support development of more practical noise-exposure protection policy.

[Ragsorters' Disease-150 years ago a new, today a vanished occupational disease in Austria]. / Die Hadernkrankheit ­ vor 150 Jahren eine neue, heute verschwundene Berufskrankheit in Österreich.

In 1870 17 women who were engaged with shredding and sorting rags in a Lower-Austrian papermill fell ill with a highly febrile lung affection; nine of them died. Hitherto this illness was not recognised as a separate disease, the "Ragsorters' Disease". The rags were used garments and household textiles collected mostly in eastern countries as well as used contaminated bandages of hospitals. The manipulation with the rags produced much dust which was inhaled by the women, provoking some different illnesses, including the Ragsorters' Disease. Mostly without prodromes a heavy lobar or lobular pneumonia with atelectasis and oedematous softenings of the lung tissue. Histologically impressive were masses of bacteria on and between the epithelia cells and inside the walls of the alveoli. The bacteria were diagnosed as Bac. anthracis.The Ragsorters' Disease could be restrained by technical improvements and disinfection. Finally, it was extinguished by the replacement of rags by woodpulp.

Case Investigations of Infectious Diseases Occurring in Workplaces, United States, 2006-2015.

Workers in specific settings and activities are at increased risk for certain infectious diseases. When an infectious disease case occurs in a worker, investigators need to understand the mechanisms of disease propagation in the workplace. Few publications have explored these factors in the United States; a literature search yielded 66 investigations of infectious disease occurring in US workplaces during 2006-2015. Reported cases appear to be concentrated in specific industries and occupations, especially the healthcare industry, laboratory workers, animal workers, and public service workers. A hierarchy-of-controls approach can help determine how to implement effective preventive measures in workplaces. Consideration of occupational risk factors and control of occupational exposures will help prevent disease transmission in the workplace and protect workers' health.

"A Widespread Superstition": The Purported Invulnerability of Workers of Color to Occupational Heat Stress.

This study explores the history of the denial of the vulnerability of non-White workers to risks of heat illness. Defenders of chattel slavery argued for the capacity of workers of African descent to tolerate extreme environmental temperatures. In Hawai'i, advocates of racial segregation emphasized the perils to Whites of strenuous work in tropical climates and the advantages of using Chinese immigrants. Growing reliance on Mexican immigrants in agriculture and other outdoor employment in the early 20th century brought forth claims of their natural suitability for unhealthful working conditions. These efforts to naturalize racial hierarchy fell apart after 1930. The Great Depression subverted the notion that people of European descent could not endure hot work. More rigorous investigation refuted contentions of racial difference in heat tolerance.

[Mobile miniature X-ray evaluation and pneumoconiosis: the role of the Clinica del Lavoro in Milan (1941-1948)]. / La valutazione schermografica delle pneumoconiosis (1941-1948): il ruolo della Clinica del Lavoro di Milano.

Since the end of the 19th century, X-rays have been used to detect lung diseases. In Italy, 207,096 miniature chest radiographs were taken from 1941 to 1948. Traditional radiographs gave better results, but miniature chest radiographs were useful for screening. Indeed, the development of mobile miniature chest radiography units resulted in an improvement in mass X-rays screening for the detection of penumoconiosis. These mobile miniature units were mounted on a bus chassis, a solution that allowed to easily reach workers. The authors analyze some models of X-ray wagon units used by the "Clinica del Lavoro" in Milan in the 1950s. From the point of view of medical museology, the preservation of these devices requires appropriate spaces.

[Concise history of toxicology - from empiric knowledge to science]. / A toxikológia rövid története ­ a tapasztalattól a tudományig.

Toxicology is a science of poisonings by xenobiotics and endogenous physiological changes. Its empiric roots may be traced back to the emerging of the human race because the most important pledge of our predecessors' survival was the differentiation between eatable and poisonous plants and animals. In the course of social evolution, there were three main fields of using poisons: 1) hunting and warfare, 2) to settle social tensions by avoiding military conflicts through hiding strategy of eliminating enemies by toxic substances, 3) medicines applied first as anti-poisons and later by introducing strong substances to defeat diseases, but paradoxically active euthanasia is also a part of the whole story. The industrial revolution of the 19th century changed the sporadic occupational diseases to mass conditions. Later the chemical industry and subsequently the mass production of synthetic materials turned out as a global environmental catastrophe. This latest change initiated the emerging of ecological toxicology which is a future history of the concerning ancient science. Orv Hetil. 2018; 159(3): 83-90.

Historical review of efforts to reduce noise-induced hearing loss in the United States.

BACKGROUND: Noise-induced hearing loss is a centuries-old problem that is still prevalent in the United States and worldwide. AIM: To describe highlights in the development of hearing loss prevention in the U.S. from World War II to the present. METHODS: Literature review. RESULTS: Approaches to occupational noise-induced hearing loss prevention in the United States over the past seven decades are described using a hierarchy of controls framework and an interdisciplinary perspective. Historical timelines and developmental milestones related to occupational noise-induced hearing loss prevention are summarized as a life course. DISCUSSION: Lessons are drawn for other countries in their hearing conservation efforts. CONCLUSION: Future developments building on the hearing loss prevention work of the past 70 years can prevent the problem of occupational NIHL in the 21st century. Am. J. Ind. Med. 60:569-577, 2017. © 2017 Wiley Periodicals, Inc.

What can 35 years and over 700,000 measurements tell us about noise exposure in the mining industry?

OBJECTIVE: To analyse over 700,000 cross-sectional measurements from the Mine Safety and Health Administration (MHSA) and develop statistical models to predict noise exposure for a worker. DESIGN: Descriptive statistics were used to summarise the data. Two linear regression models were used to predict noise exposure based on MSHA-permissible exposure limit (PEL) and action level (AL), respectively. Twofold cross validation was used to compare the exposure estimates from the models to actual measurement. The mean difference and t-statistic was calculated for each job title to determine whether the model predictions were significantly different from the actual data. STUDY SAMPLE: Measurements were acquired from MSHA through a Freedom of Information Act request. RESULTS: From 1979 to 2014, noise exposure has decreased. Measurements taken before the implementation of MSHA's revised noise regulation in 2000 were on average 4.5 dBA higher than after the law was implemented. Both models produced exposure predictions that were less than 1 dBA different than the holdout data. CONCLUSION: Overall noise levels in mines have been decreasing. However, this decrease has not been uniform across all mining sectors. The exposure predictions from the model will be useful to help predict hearing loss in workers in the mining industry.

Universal Expositions, physics-chemistry and new occupational diseases: the case of Marie Sklodowska Curie and radium girls. / Esposizioni universali, la fisica-chimica e le nuove malattie da lavoro: il caso di Marie Sklodowska Curie e le ragazze del radio.

BACKGROUND: Radium discovery by Marie and Pierre Curies caused previously unknown diseases. Marie Sklodowska Curie (1867-1934) suffered from radiations effects, as did girls in the radium dial watches factories. Therapeutic effects of radium were soon discovered, its unhealthy effects were as yet unheard of. OBJECTIVES: Analysis of Marie Sklodowska Curie (Marie) and radium girls occupational exposure, taking scientific debate on radium dangerous effects into account. METHODS: analysis of occupational exposure and diseases of Marie and radium girls in major documents, including Curie archive letters. RESULTS: Marie had dermatitis, radiodermatitis, tinnitus, one abortion, cataracts, tubercolosis, aplastic anemia. She also was a victim of mobbing. Women employed in the New Jersey radium dial watches factories, often immigrants, died of jaw necrosis, sarcoma of femur, anemia, leukemia and other radium related diseases. Marie was first asked about radium adverse effects by the New Jersey Department of labour (1925), Lise Meitner (1928) and the American Society for Cancer Control (1929). In 1928 Alice Hamilton organized a radium conference in order to find a solution to the radium girls' new disease. In 1929, during her second visit to the United States of America (USA), Marie declared how only prevention could save "radium girls". In 1934 she died of aplastic anemia, just like many radium girls. That year International Labour Office listed the new disease as due to "radium, radioactive substances, X-rays"; it was followed in 1937 by five USA states. CONCLUSIONS: Unheard of knowledge, conflict of interest, scientific delay, incompetence and no prevention were yesterday, as they are today, the cause of many preventable women deaths.

Historical state of knowledge of the health risks of asbestos posed to seamen on merchant ships.

We examined the development of knowledge concerning the risks posed by asbestos to seamen working aboard merchant ships at sea (i.e. commercial, rather than naval vessels). Seamen were potentially exposed to "in-place" asbestos on merchant ships by performing intermittent repair and maintenance tasks. We reviewed studies measuring airborne asbestos onboard merchant ships and health outcomes of merchant seamen, as well as studies, communications, and actions of U.S. organizations with roles in maritime health and safety. Up to the 1970s, most knowledge of the health risks of asbestos was derived from studies of workers in asbestos product manufacturing and asbestos mining and milling industries, and certain end-users of asbestos products (particularly insulators). We found that attention to the potential health risks of asbestos to merchant seamen began in the mid- to late 1970s and early 1980s. Findings of pleural abnormalities in U.S. seamen elicited some concern from governmental and industry/labor organizations, but airborne asbestos concentrations aboard merchant ships were found to be <1 f/cc for most short-term repair and maintenance tasks. Responses to this evolving information served to warn seamen and the merchant shipping industry and led to increased precautions regarding asbestos exposure. Starting in the 1990s, findings of modest increases in lung cancer and/or mesothelioma in some epidemiology studies of seamen led some authors to propose that a causal link between shipboard exposures and asbestos-related diseases existed. Limitations in these studies, however, together with mostly unremarkable measures of airborne asbestos on merchant ships, preclude definitive conclusions in this regard.

[Main stages of occupational pathology development in Russia].

The authors attempted to follow history of national occupational pathology development, analyzed features of its formation of Russian Federation territory, presented main stages and key moments of its establishment in XIX-XXI centuries.

To jubilee of Federal State Budgetary Scientific institution <>.

The author presents results in main scientific trends developed in the Institute since its foundation and prospects of further advances in public health and healthcare, hygiene, industrial medicine, human ecology.

Miners, silica and disability: The bi-national interplay between South Africa and the United Kingdom, c1900-1930s.

This paper investigates silicosis as a disabling disease in underground mining in the United Kingdom (UK) before Second World War, exploring the important connections between South Africa and the UK and examining some of the issues raised at the 1930 International Labour Office Conference on silicosis in Johannesburg in a British context. The evidence suggests there were significant paradoxes and much contestation in medical knowledge creation, advocacy, and policy-making relating to this occupational disease. It is argued here that whilst there was an international exchange of scientific knowledge on silicosis in the early decades of the twentieth century, it was insufficient to challenge the traditional defense adopted by the British government of proven beyond all scientific doubt before effective intervention in coal mining. This circumspect approach reflected dominant business interests and despite relatively robust trade union campaigning and eventual reform, the outcome was an accumulative legacy of respiratory disease and disability that blighted coalfield communities.

From the 1930 International Johannesburg conference on silicosis, to "tables" of occupational diseases, France, 2000 onward: A comparative reading.

Through the concept of "thought collectives" in particular, Ludwik Fleck was a pioneer in demonstrating how much scientific knowledge is inherently made up of social and historical material. In this article, I propose to follow a Fleckian path by comparing the proceedings of the 1930 International Labour Office Conference on silicosis in Johannesburg on the one hand, and on the other the content of the debates that took place in France in the 2000s to revise the "tables" of occupational diseases which define the compensation rules for salaried workers in the French general (as well as the farm) health insurance scheme. The text offers an analysis of the striking similarities between these two distant sources, pointing out particularly the repetitiveness of ignorance and knowledge, and the nature of what can be admitted as a body of "evidence" in medico-legal issues such as the definition and compensation of occupational diseases.

"Bernardino Ramazzini, three hundred years after his death", Padua (Italy), October 18th, 2014.

The year 2014 has marked the tercentenary from the death of Bernardino Ramazzini (1633-1714), universally credited as the founder of Occupational Health (5, 9, 10, 11). Indeed, the renowned physician died on November 5th 1714 in Padua, where he had been appointed as Professor of Practical Medicine at the local prestigious University from the year 1700. To commemorate this anniversary, the professors of Occupational Health of the University of Padua, the Italian Society of Occupational Health and Industrial Hygiene (Società Italiana di Medicina del Lavoro eIgiene Industriale, SIMLII), the International Commission on Occupational Health (ICOH) and the University of Padua organized a conference in the wonderful location of Palazzo Bo (Main Hall) under the patronage of the Padua Municipality, the Workers' Compensation Authority (INAIL), the Venetian Region and the Societas Internationalis Historiae Medicinae.[...].

Profiles in Performing Arts Medicine Courage--A Tribute to Dr. Alice Brandfonbrener.

I was honored and privileged to join Dr. Robert Sataloff in delivering a tribute to Dr. Alice Brandfonbrener at the 2015 Symposium on the Medical Problems of Performing Artists in Snowmass, Colorado. As virtually everyone who reads this journal knows, Dr. Brandfonbrener organized the first symposium (then focused on the medical problems of musicians), was the founding editor of Medical Problems of Performing Artists, and was the first president of the Performing Arts Medicine Association. She died in 2014, just prior to last year's symposium. This year, after Dr. Sataloff presented a very engaging overview of Alice's career and impressive accomplishments, I gave a short address that was based on some of the editorials Alice wrote in this journal during her 20 year tenure as editor. I have chosen a few examples of how the courage that she demonstrated in launching an international medical conference, a peer-reviewed medical journal, and a professional association continued to present itself in her writing.

[To 70th anniversary of the Victory: activities of V.A. Obukh Central Institute for Industrial hygiene and Occupational diseases with USSR Narkomzdrav during Great Patriotic War].

The article covers data on activities of scientists and staffers of VA. Obukh Central Institute for Industrial hygiene and Occupational diseases with USSR Narkomzdrav during Great Patriotic War, on role of occupational therapists and hygienists in solving problems of better medical and sanitary care for workers engaged into defence industry.