RESUMO
OBJECTIVES: Evaluation of a standardised management for the treatment of patients with parapneumonic empyema. METHODS: A retrospective 10-year single-centre analysis of all patients with parapneumonic empyema undergoing a standardised thoracoscopic treatment approach. We describe referral and age patterns, microbiological results, overall and stage-dependent success rates, conversion rates, 30-day and in-hospital mortality. RESULTS: From May 2003 to April 2013, 248 patients with parapneumonic empyemas were treated in our centre. Most patients were referred at weekends, and younger patients had advanced stages. The cure rate in stage I was 97.6â% and reached 80.3â% in stage II and 63.1â% in stage III. 6 patients (2.4â%) (all stage III) needed conversion to an open procedure. A revision was required in 19.7â% of cases in stage II and 27.7â% in stage III. 30-day mortality was 4.8â%, in-hospital mortality was 8.1â%. CONCLUSION: A standardised approach, including VATS, is associated with a high cure, low revision and moderate conversion rates. In view of a still considerable mortality, a higher index of suspicion and detection of advanced stages, especially in younger patients, is required to improve outcomes.
Assuntos
Empiema/cirurgia , Cirurgia Torácica Vídeoassistida , Toracostomia , Empiema/mortalidade , Alemanha/epidemiologia , Mortalidade Hospitalar , Humanos , Tempo de Internação , Masculino , Derrame Pleural/cirurgia , Estudos Retrospectivos , Resultado do TratamentoRESUMO
BACKGROUND: Pseudomonas aeruginosa is a cause of infections of the lower respiratory tract among patients with chronic lung disorders. It is questionable whether virulence of this species may be influenced by multidrug resistance (MDR). OBJECTIVES: To define the impact of MDR in experimental lung infection. METHODS: Experimental empyema was induced in rabbits by MDR (group A, n = 16) and by susceptible isolates (group B, n = 10). Pleural fluid was sampled for quantitative culture and estimation of cell apoptosis and of tumor necrosis factor-alpha (TNFα) and malondialdehyde (MDA). Survival was recorded. Cytokine production was stimulated in U937 monocytes by samples of pleural fluid. Whole blood of rabbits was incubated with the isolates; induction of apoptosis was assessed. RESULTS: Survival of group A was prolonged compared to group B. This was accompanied by lower bacterial counts of the inoculated pathogens in pleural fluid and in the lungs of group A compared with group B. Early apoptosis of neutrophils of pleural fluid of group A was lower compared with group B. Pleural fluid concentrations of TNFα and MDA did not differ between the groups. Cytokine production by U937 monocytes after stimulation with pleural fluid was greater in group B than in group A. The susceptible isolate induced apoptosis of neutrophils in vitro at a greater rate than the MDR isolate. CONCLUSIONS: Experimental empyema by susceptible P. aeruginosa is accompanied by greater mortality compared with MDR P. aeruginosa. This phenomenon may be attributed to the different growth pattern of the pathogens or to their interaction with the innate immune system.
Assuntos
Farmacorresistência Bacteriana Múltipla , Empiema/microbiologia , Infecções por Pseudomonas/complicações , Infecções por Pseudomonas/tratamento farmacológico , Pseudomonas aeruginosa/efeitos dos fármacos , Pseudomonas aeruginosa/fisiologia , Animais , Carga Bacteriana , Citocinas/biossíntese , Suscetibilidade a Doenças , Farmacorresistência Bacteriana Múltipla/fisiologia , Empiema/mortalidade , Humanos , Imunidade Inata/fisiologia , Pulmão/microbiologia , Masculino , Malondialdeído/metabolismo , Monócitos/metabolismo , Neutrófilos , Derrame Pleural/patologia , Derrame Pleural/fisiopatologia , Pseudomonas aeruginosa/crescimento & desenvolvimento , Pseudomonas aeruginosa/patogenicidade , Coelhos , Especificidade da Espécie , Taxa de Sobrevida , Fator de Necrose Tumoral alfa/metabolismo , Células U937/metabolismo , Virulência/fisiologiaRESUMO
Pneumococcal/lobar pneumonia and empyema have an important impact on the health of children worldwide. There has been no epidemiological study of pneumococcal/lobar pneumonia and empyema in Taiwan, a middle-income Asian population. Using Taiwan's National Health Insurance database, we collected and analyzed data obtain from medical care claims related to pneumococcal/lobar pneumonia and empyema for children below the 18 years old from 1997 to 2004. We found the annual population-based incidence to have significant year to year increases and the average annual incidences of pneumococcal/lobar pneumonia and empyema in children under five to be 44.9 and 10.5 episodes per 100,000 children-year, respectively. About 64% of children with pneumococcal/lobar pneumonia and empyema were under 5 years old. Children 4 to 5 years old had the highest incidences of both pneumococcal/lobar pneumonia and empyema. Incidence was the highest each spring. The odds ratio of the case fatality among pneumococcal/lobar pneumonia patients complicated with empyema to those without was 118 (95% confidence interval 28-492). In conclusion, the population-based incidences of pneumococcal/lobar pneumonia and empyema among children under five in Taiwan were 44.9 and 10.5 episodes per 100,000 children-year, respectively, and 4- to 5-year-old children had the highest incidences of both pneumococcal/lobar pneumonia and empyema. This population might benefit from a universal pneumococcal vaccination program which might cover about 70% of invasive pneumococcal diseases in Taiwanese children under 5 years old.
Assuntos
Empiema/epidemiologia , Pneumonia Pneumocócica/epidemiologia , Pneumonia/epidemiologia , Adolescente , Distribuição por Idade , Criança , Pré-Escolar , Empiema/mortalidade , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Pneumonia/mortalidade , Pneumonia Pneumocócica/mortalidade , Estações do Ano , Distribuição por Sexo , Taiwan/epidemiologiaRESUMO
OBJECTIVE: Evaluate the cost-effectiveness ratio of the program for universal vaccination with heptavalent pneumococcal conjugate vaccine (PCV7) in children under 5 years of age in Uruguay. METHODS: A Markov model was developed that simulated a cohort of 48 000 children born in 2007 and their progress to age 76. The baseline case used a regimen of three doses with estimated protection for five years. The presumption of vaccine efficacy and effectiveness was based on studies conducted in the United States with adjustment for serotype prevalence-incidence in Uruguay. The results were expressed as the incremental cost per life year gained (LYG) and quality-adjusted life year (QALY) [gained]. RESULTS: For the baseline case, the incremental cost was US $7334.60 for each LYG and US $4655.80 for each QALY. Eight deaths and 4 882 cases of otitis, 56 cases of bacteremia-sepsis, 429 cases of pneumonia, and 7 cases of meningitis were prevented. The model shows sensitivity to variations in vaccine cost, efficacy, and pneumonia-related mortality. CONCLUSIONS: The universal vaccination program with PCV7 in Uruguay is highly cost-effective. Therefore, it is recommended for other countries with burden of pneumococcal disease and serotype coverage similar to those of Uruguay.
Assuntos
Vacinas Pneumocócicas/economia , Vacinação/economia , Bacteriemia/mortalidade , Bacteriemia/prevenção & controle , Simulação por Computador , Análise Custo-Benefício , Empiema/mortalidade , Empiema/prevenção & controle , Gastos em Saúde , Vacina Pneumocócica Conjugada Heptavalente , Humanos , Incidência , Cadeias de Markov , Modelos Teóricos , Otite Média/epidemiologia , Otite Média/prevenção & controle , Infecções Pneumocócicas/economia , Infecções Pneumocócicas/mortalidade , Infecções Pneumocócicas/prevenção & controle , Anos de Vida Ajustados por Qualidade de Vida , Sepse/mortalidade , Sepse/prevenção & controle , Uruguai , Vacinas Conjugadas/economiaRESUMO
BACKGROUND: Empyema is a rare, but morbid complication of diaphragmatic injury. The purpose of this study was to use the National Trauma Databank of the American College of Surgeons to determine (1) the incidence of empyema after diaphragmatic injury, (2) risk factors for development of empyema after these injuries, and (3) the effect of empyema on mortality, hospital, and intensive care unit (ICU) length of stay (LOS) after diaphragm injury. METHODS: The National Trauma Databank (v. 5.0) was used to identify adult patients sustaining diaphragmatic injury and surviving for greater than 48 hours. Demographics, injury characteristics, associated abdominal injuries, thoracic procedures, and outcomes data were abstracted for comparison of patients who did and did not develop empyema after these injuries. Stepwise logistic regression analysis was used to identify independent risk factors for the development of empyema. Subsequent adjusted analysis was used to determine the effect of empyema on outcomes (hospital LOS, ICU LOS, mortality). RESULTS: Among 4,153 patients with diaphragmatic injury who survived more than 48 hours from admission, 57 (1.4%) developed empyema. Demographics did not differ significantly between the two groups. Empyema was associated with longer adjusted mean hospital (35.9 vs. 16.1, p < 0.001) and ICU (18.1 vs. 8.5, p < 0.001) LOS, but was not associated with increased mortality. Patients with empyema more commonly had associated hollow viscus (63.2% vs. 35.6%, p < 0.001), gastric (40.4% vs. 18.8%, p < 0.001), and splenic injuries (49.1% vs. 33.3%, p = 0.01). After multivariable analysis, two independent risk factors for the development of empyema after diaphragmatic injury were identified: gastric injury (adjusted odds ratio = 2.90; 95% confidence interval: 1.69-5.00; p < 0.001) and Injury Severity Score > or = 20 (adjusted odds ratio = 2.99; 95% confidence interval: 1.61-5.59; p = 0.001). Concomitant colonic injury did not significantly increase the risk of empyema in the study population. CONCLUSIONS: Empyema is an uncommon sequela of diaphragm injury that contributes to the need for prolonged hospital and ICU LOSs. Associated gastric trauma and Injury Severity Score > or = 20 were independently associated with empyema development after diaphragmatic injury.
Assuntos
Diafragma/lesões , Empiema/epidemiologia , Adulto , Bases de Dados como Assunto , Empiema/etiologia , Empiema/mortalidade , Feminino , Hospitais , Humanos , Incidência , Unidades de Terapia Intensiva , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Estados Unidos , Adulto JovemRESUMO
OBJECTIVES: Feline intracranial abscessation or empyema is infrequently reported in the veterinary literature. To date, the largest study is based on a population of 19 cats with otogenic infection. The aim of this study was to review a larger population of cats with intracranial empyema from multiple aetiologies and document their signalment, imaging findings, treatment protocols (including medical and/or surgical management) and to compare outcomes. METHODS: Cases presenting to a single referral centre over a 10 year period with compatible history, neurological signs and imaging findings consistent with intracranial abscessation and empyema were reviewed retrospectively. RESULTS: Twenty-three cats met the inclusion criteria. Advanced imaging (CT and/or MRI) was performed in 22/23 cats; one case was diagnosed via ultrasound. Ten cases underwent medical and surgical management combined, 10 underwent solely medical management and three were euthanased at the time of diagnosis. Short-term outcome showed that 90% of surgically managed and 80% of medically managed cats were alive at 48 h post-diagnosis. Long-term survival showed that surgically managed cases and medically managed cases had a median survival time of 730 days (range 1-3802 days) and 183 days (range 1-1216 days), respectively. No statistical significance in short- or long-term survival ( P >0.05) was found between medically and surgically managed groups. CONCLUSIONS AND RELEVANCE: Feline intracranial abscessation and empyema are uncommon conditions that have historically been treated with combined surgical and medical management. This study documents that, in some cases, intracranial abscessation and empyema can also be successfully treated with medical management alone.
Assuntos
Doenças do Gato , Infecções do Sistema Nervoso Central , Empiema , Animais , Doenças do Gato/diagnóstico por imagem , Doenças do Gato/mortalidade , Doenças do Gato/terapia , Gatos , Infecções do Sistema Nervoso Central/diagnóstico por imagem , Infecções do Sistema Nervoso Central/mortalidade , Infecções do Sistema Nervoso Central/terapia , Infecções do Sistema Nervoso Central/veterinária , Empiema/diagnóstico por imagem , Empiema/mortalidade , Empiema/terapia , Empiema/veterinária , Imageamento por Ressonância Magnética , Estudos RetrospectivosRESUMO
BACKGROUND: Cotrimoxazole prophylaxis reduces morbidity and mortality in HIV-1-infected children, but mechanisms for these benefits are unclear. METHODS: CHAP was a randomized trial comparing cotrimoxazole prophylaxis with placebo in HIV-infected children in Zambia where background bacterial resistance to cotrimoxazole is high. We compared causes of mortality and hospital admissions, and antibiotic use between randomized groups. RESULTS: Of 534 children (median age, 4.4 years; 32% 1-2 years), 186 died and 166 had one or more hospital admissions not ending in death. Cotrimoxazole prophylaxis was associated with lower mortality, both outside hospital (P = 0.01) and following hospital admission (P = 0.005). The largest excess of hospital deaths in the placebo group was from respiratory infections [22/56 (39%) placebo versus 10/35 (29%) cotrimoxazole]. By 2 years, the cumulative probability of dying in hospital from a serious bacterial infection (predominantly pneumonia) was 7% on cotrimoxazole and 12% on placebo (P = 0.08). There was a trend towards lower admission rates for serious bacterial infections in the cotrimoxazole group (19.1 per 100 child-years at risk versus 28.5 in the placebo group, P = 0.09). Despite less total follow-up due to higher mortality, more antibiotics (particularly penicillin) were prescribed in the placebo group in year one [6083 compared to 4972 days in the cotrimoxazole group (P = 0.05)]. CONCLUSIONS: Cotrimoxazole prophylaxis appears to mainly reduce death and hospital admissions from respiratory infections, supported further by lower rates of antibiotic prescribing. As such infections occur at high CD4 cell counts and are common in Africa, the role of continuing cotrimoxazole prophylaxis after starting antiretroviral therapy requires investigation.
Assuntos
Anti-Infecciosos/uso terapêutico , Infecções por HIV/tratamento farmacológico , HIV , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , Antituberculosos/uso terapêutico , Contagem de Linfócito CD4 , Causas de Morte , Criança , Pré-Escolar , Progressão da Doença , Farmacorresistência Bacteriana , Empiema/mortalidade , Empiema/virologia , Infecções por HIV/imunologia , Infecções por HIV/mortalidade , Mortalidade Hospitalar , Hospitalização , Humanos , Lactente , Pneumonia/mortalidade , Pneumonia/virologia , ZâmbiaRESUMO
Toxoplasma gondii is an opportunistic parasite that can cause severe disease in immunosuppressed individuals. We report a case of unsuspected T. gondii empyema in a bone marrow transplant recipient that was diagnosed by the visualization of numerous intracellular and extracellular tachyzoites in Giemsa- and Gram-stained smears. The patient was treated with pyrimethamine, sulfadiazine, clindamycin, and atovaquone, and she survived 110 days after diagnosis, despite having a large parasite burden.
Assuntos
Empiema/parasitologia , Infecções Oportunistas/parasitologia , Toxoplasma , Toxoplasmose/parasitologia , Adulto , Animais , Transplante de Medula Óssea/efeitos adversos , Empiema/tratamento farmacológico , Empiema/epidemiologia , Empiema/mortalidade , Evolução Fatal , Feminino , Humanos , Pneumopatias/epidemiologia , Pneumopatias/parasitologia , Fatores de Risco , Toxoplasma/efeitos dos fármacos , Toxoplasmose/tratamento farmacológico , Toxoplasmose/epidemiologia , Toxoplasmose/mortalidadeRESUMO
Empyema thoracis following pneumonia, trauma, and surgical procedures continues to be a source of major morbidity and mortality. We retrospectively reviewed the hospital records of 100 patients treated for empyema thoracis at San Francisco General Hospital during the past 10 years. The causes of empyema in these patients were as follows: pneumonia 44%, trauma 24%, surgical and invasive procedures 15%, lung abscess 11%, and hematogenous spread 6%. Ten patients in this series died of sepsis from necrotizing pneumonia or overwhelming injuries caused by trauma. Streptococcus (31%), Staphylococcus (21%), and Bacteroides (15%) were the organisms most commonly isolated. Bacterial isolates were single in 55%, multiple 42%, and absent in 3%. The type of organism did not correlate with severity of disease or eventual requirement for thoracotomy, pleural débridement, or Eloesser procedure. Successful methods of treatment included aspiration in 9%, tube thoracostomy in 63%, pleural débridement and drainage in 7%, and an Eloesser procedure in 11%. Because our patients were often debilitated from chronic alcoholism, drug addiction, and major trauma, conservative management was initially tried. In most patients empyema resolved with tube thoracostomy. Pleural débridement should be reserved for patients with special problems such as multiple loculation or purulence inaccessible to percutaneous tube placement. the Eloesser procedure is indicated in patients who have an infected residual pleural space that persists despite adequate tube drainage.
Assuntos
Empiema/mortalidade , Cirurgia Torácica/métodos , Adolescente , Adulto , Idoso , Drenagem , Empiema/diagnóstico por imagem , Empiema/microbiologia , Empiema/cirurgia , Empiema/terapia , Feminino , Humanos , Pessoa de Meia-Idade , RadiografiaRESUMO
I have reviewed the literature concerning the effect of postoperative sepsis on survival following resection for carcinoma of the bronchus and added to this my experience over a 12 year period. Surgeons agree that because of its morbidity and the morbidity of measures necessary for its treatment, postoperative empyema is to be avoided, but many still hope that some compensation might be afforded the unfortunate sufferer by improvement in long-term survival. I have not found this to be the case and I feel that statistical evidence favors this view.
Assuntos
Neoplasias Brônquicas/cirurgia , Empiema/etiologia , Pneumonectomia/mortalidade , Complicações Pós-Operatórias/etiologia , Adulto , Idoso , Neoplasias Brônquicas/mortalidade , Empiema/imunologia , Empiema/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , EscóciaRESUMO
Pleural complications occurred in 30 (22%) of 138 patients after 53 single and 91 double lung transplants between September 1986 and February 1993. These were defined for the purpose of this study as pneumothorax persisting beyond the first 14 postoperative days, recurrent pneumothorax, or any other pleural process that necessitated diagnostic or therapeutic intervention. Overall, a higher pleural complication rate was seen in double lung transplantation (25 of 30) than in single lung transplantation (5 of 30) with no differences noted in the frequency among preoperative diagnostic groups (p > 0.05). Pneumothorax was the most frequent complication, affecting 14 of 30 patients, with 6 of 14 cases occurring after transbronchial biopsy. All pneumothoraces in single (n = 4) and double lung transplantation (n = 10) resolved spontaneously or with chest tube thoracostomy. One patient required placement of a Clagett window after open lung biopsy and another required thoracotomy and pleural abrasion after transbronchial biopsy. Parapneumonic effusion was observed in 4 of 30 double lung transplantations with spontaneous resolution in all cases. Empyema affected 7 of 30 patients and occurred exclusively in the double lung transplant group. Sepsis developed in three of the patients with this complication and they subsequently died. The risk of empyema was independent of preoperative diagnosis (p > 0.05). Of interest, all patients with cystic fibrosis (n = 3) with complicating empyema had Pseudomonas cepacia in the pleural fluid. Other miscellaneous complications included subpleural hematoma, chylothorax, and hemothorax. The latter two necessitated thoracic duct and bronchial artery ligation, respectively. In summary, a significant proportion of lung transplant recipients will have pleural space complications. The vast majority of these will resolve spontaneously or with conservative procedures. These complications were not related to preoperative diagnosis nor associated with a significant prolongation of hospital stay (p > 0.05). Empyema is the only pleural space complication associated with increased patient mortality and, as such, is an important clinical marker for those at risk for sepsis and death.
Assuntos
Transplante de Pulmão/efeitos adversos , Doenças Pleurais/etiologia , Pneumotórax/etiologia , Adulto , Burkholderia cepacia/isolamento & purificação , Distribuição de Qui-Quadrado , Fibrose Cística/complicações , Empiema/etiologia , Empiema/mortalidade , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Derrame Pleural/microbiologia , Infecções por Pseudomonas/etiologia , Pseudomonas aeruginosa/isolamento & purificação , Recidiva , Fatores de Risco , Análise de SobrevidaRESUMO
The thoracic complications of amebiasis frequently necessitate surgical intervention. Experience with 28 patients is presented. Involvement included the pleura in 19 patients, the lungs in 10, and the pericardium in five. In 25%, more than one site was involved. Treatment consisted of measures designed to obliterate the pleural space or widely drain the pericardial sac, as indicated. Concurrent drainage of the associated amebic liver abscess was done in half the cases. The mortality rate was 36%, generally related to the poor general condition of the patients and their delay in seeking hospitalization.
Assuntos
Amebíase/cirurgia , Pneumopatias/cirurgia , Pericardite/cirurgia , Doenças Pleurais/cirurgia , Adolescente , Adulto , Amebíase/mortalidade , Criança , Pré-Escolar , Drenagem , Empiema/etiologia , Empiema/mortalidade , Empiema/cirurgia , Feminino , Humanos , Lactente , Abscesso Hepático Amebiano/complicações , Abscesso Hepático Amebiano/mortalidade , Abscesso Hepático Amebiano/cirurgia , Pneumopatias/mortalidade , Masculino , Pessoa de Meia-Idade , Derrame Pericárdico/etiologia , Derrame Pericárdico/mortalidade , Derrame Pericárdico/cirurgia , Pericardite/mortalidade , Doenças Pleurais/mortalidade , Derrame Pleural/etiologia , Derrame Pleural/mortalidade , Derrame Pleural/cirurgia , Costelas/cirurgia , Ruptura Espontânea , Toracoplastia , TraqueotomiaRESUMO
From 1959 to 1974, 542 patients underwent curative resection for bronchogenic carcinoma. Postoperative empyema occurred in 17 of these patients. The overall 5-year survival of these 17 patients was only 18%, compared with 27% in the 525 patients without empyema. We were unable to demonstrate by our study or by a review of the literature that postoperative empyema favorably influences survival in patients who have had pulmonary resection for bronchogenic carcinoma.
Assuntos
Empiema/mortalidade , Neoplasias Pulmonares/cirurgia , Idoso , Carcinoma Broncogênico , Empiema/etiologia , Feminino , Humanos , Neoplasias Pulmonares/mortalidade , Masculino , Pessoa de Meia-Idade , Complicações Pós-OperatóriasRESUMO
Acute nontuberculous empyema treated conventionally by thoracentesis, thoracostomy drainage, and antibiotics has an unacceptably high rate of morbidity and mortality. Early open thoracotomy to eliminate the empyema with decortication of the fibrinous peel and reexpansion of the lung has proven safe and effective for 25 years. The goals of treatment of acute nontuberculous empyema are: (1) to save life, (2) to eliminate the empyema, (3) to reexpand the trapped lung, (4) to restore mobility of the chest wall and diaphragm, (5) to return respiratory function to normal, (6) to eliminate complications or chronicity, and (7) to reduce the duration of hospital stay. Our studies confirm the normal values to be expected in patients who have had complete recovery from the acute empyema, and we lay to rest any concern that decortication might, in time, limit pulmonary function. We present the cases of 21 children who had acute and mature empyemas that were treated by open thoracotomy and decortication, with an average follow-up of 18 years, among whom there were no deaths or complications.
Assuntos
Empiema/cirurgia , Doença Aguda , Criança , Pré-Escolar , Diafragma/cirurgia , Empiema/mortalidade , Empiema/fisiopatologia , Feminino , Humanos , Lactente , Pulmão/cirurgia , Medidas de Volume Pulmonar , Masculino , Cirurgia TorácicaRESUMO
There is much disagreement in the literature about the beneficial effect of postpneumonectomy empyema on survival following operation for bronchogenic carcinoma. We had the opportunity to gather data on 407 patients with this serious complication. The survival data for a group of patients with postpneumonectomy empyema and fistula were compared with those for another group without such complications. Our statistical analysis confirms that postpneumonectomy empyema does not improve life expectancy.
Assuntos
Carcinoma Broncogênico/mortalidade , Empiema/etiologia , Neoplasias Pulmonares/mortalidade , Pneumonectomia/efeitos adversos , Fístula Brônquica/etiologia , Fístula Brônquica/mortalidade , Carcinoma Broncogênico/cirurgia , Empiema/mortalidade , Humanos , Neoplasias Pulmonares/cirurgia , Complicações Pós-Operatórias/mortalidadeRESUMO
A retrospective evaluation of 199 consecutive patients undergoing resection for lung cancer revealed a significantly shorter long-term survival for those in whom empyema developed postoperatively. The overall five-year survival for the empyema group was 24% compared with 35% in the control group (patients without empyema), and the median survival was 15 months for the control group. These differences in survival were not found among patients with Stage I lung cancer. Pneumonectomy proved to be the main risk factor for the occurrence of empyema after operation, but a minor risk factor was the anatomical extent of disease. this correlation may be explained by major surgical contamination or manipulation as well as by lower immunological host reaction, all related to the extent of the tumor. A lower immunological defense could also explain the worse outcome for patients with Stage II or III lung cancer in whom empyema developed postoperatively.
Assuntos
Empiema/complicações , Neoplasias Pulmonares/complicações , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Empiema/imunologia , Empiema/mortalidade , Feminino , Humanos , Lactente , Recém-Nascido , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Pneumonectomia , Estudos RetrospectivosRESUMO
One hundred two patients with empyema thoracis were managed at the Royal Melbourne Hospital between 1976 and 1989. Fifty-five cases of empyema thoracis were postpneumonic, 8 followed esophageal rupture, and 5 were associated with thoracic trauma. Some form of systemic illness was a major contributing factor in the presentation of 29 patients. A single causal organism was found in 53 patients (the most common being Staphylococcus aureus), multiple organisms in 36, and no growth in 13. During the years 1983 to 1989 there was an increased incidence of empyemas caused by multiple or antibiotic-resistant organisms. Operative drainage was required in 90 patients and 12 were managed by thoracentesis or intercostal tube drainage alone. The in-hospital mortality rate for patients managed nonoperatively was 58% (7 of 12 patients); it was 16% (14 of 90 patients) for those receiving operative drainage. There were seven late deaths, four empyema related and three nonrelated. Early adequate operative drainage is recommended for patients with empyema thoracis.
Assuntos
Empiema/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Drenagem/métodos , Empiema/etiologia , Empiema/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pneumonectomia/efeitos adversos , Complicações Pós-Operatórias/mortalidade , Estudos Retrospectivos , Taxa de Sobrevida , Toracoplastia/métodos , Toracotomia/métodosRESUMO
The authors report their experience with 30 cases of intracranial suppuration: 23 with brain abscess and seven with subdural empyema. All of the cases were diagnosed by means of computerized tomography and enhancement with intravenous contrast material. Most of the patients were treated by single or repeated aspiration through burr holes.
Assuntos
Abscesso Encefálico/diagnóstico por imagem , Encefalopatias/diagnóstico por imagem , Empiema/diagnóstico por imagem , Meninges , Espaço Subdural , Tomografia Computadorizada por Raios X , Abscesso Encefálico/mortalidade , Abscesso Encefálico/cirurgia , Encefalopatias/mortalidade , Encefalopatias/cirurgia , Empiema/mortalidade , Empiema/cirurgia , HumanosRESUMO
One hundred consecutive patients underwent surgical procedures for empyema. Sixty-six patient acquired empyema from pneumonia, 16 from trauma, 11 from abdominal sepsis, and 7 from other causes. If tube thoracostomy failed, computerized tomography and ultrasonography were used to demonstrate a loculated empyema. After a median observation period of 11 days, 91 patients underwent thoracotomy and decortication and 9 patients underwent either rib resection, an Eloesser flap procedure, or both. The mortality rate was 6 percent 30 days postoperatively, the in-hospital mortality rate was 9 percent, and the overall morbidity rate was 17 percent. An excellent result was achieved in 85 percent of the patients with a recurrence rate of 4 percent. Gram-positive aerobes were the most common organisms cultured, but several opportunistic infections were encountered. We have concluded that early thoracotomy and decortication of empyema results in eradication of difficult pleural infections with hospital stays of an acceptable length and reasonably low morbidity and mortality rates.
Assuntos
Empiema/cirurgia , Empiema/tratamento farmacológico , Empiema/microbiologia , Empiema/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pleura/cirurgia , Recidiva , ToracotomiaRESUMO
During an 181/2 year period, we encountered 14,300 patients with blunt or penetrating thoracic or thoracicoabdominal trauma. In 155 patients, residual clotted hemothorax or empyema developed later. Thirty-nine patients underwent early evacuation of clotted hemothorax with no mortality and an average hospital stay of only 10 days. When progression to empyema occurred, the mortality rate increased to 9.4 percent and the average hospital stay to 37.9 days. The most common related event in the development of empyema was concurrent injury to intraabdominal organs and the inevitable bacterial contamination of the thorax. In a small number of patients, tube thoracostomy drainage is inadequate and results in residual clotted hemothorax. Despite recent pleas for conservative, expectant management, it is our experience that early evacuation of clotted hemothorax is not only cost-effective, it is also associated with lower morbidity, lower mortality, and reduces the chance of development of empyema.