Complete nucleotide sequence analysis of a Brazilian dengue virus type 2 strain
Mem. Inst. Oswaldo Cruz
; 97(7): 991-995, Oct. 2002. ilus, tab
Article
em En
| LILACS
| ID: lil-325922
Biblioteca responsável:
BR1.1
RESUMO
In the last decade, dengue fever (DF) in Brazil has been recognized as an important public health problem, and an increasing number of dengue haemorrhagic fever (DHF) cases have been reported since the introduction of dengue virus type 2 (DEN-2) into the country in 1990. In order to analyze the complete genome sequence of a DEN-2 Brazilian strain (BR64022/98), we designed primers to amplify contiguous segments of approximately 500 base pairs across the entire sequence of the viral genome. Twenty fragments amplified by reverse transcriptase-PCR were cloned, and the complete nucleotide and the deduced amino acid sequences were determined. This constitutes the first complete genetic characterization of a DEN-2 strain from Brazil. All amino acid changes differentiating strains related to the Asian/American-Asian genotype were observed in BR64022/98, indicating the Asiatic origin of the strain
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
RNA Viral
/
Sequência de Bases
/
Sequência de Aminoácidos
/
Genoma Viral
/
Vírus da Dengue
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
/
Estados Unidos