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Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.
Rapley, E A; Crockford, G P; Teare, D; Biggs, P; Seal, S; Barfoot, R; Edwards, S; Hamoudi, R; Heimdal, K; Fossâ, S D; Tucker, K; Donald, J; Collins, F; Friedlander, M; Hogg, D; Goss, P; Heidenreich, A; Ormiston, W; Daly, P A; Forman, D; Oliver, T D; Leahy, M; Huddart, R; Cooper, C S; Bodmer, J G; Easton, D F; Stratton, M R; Bishop, D T.
Afiliação
  • Rapley EA; Sections of Cancer Genetics and Molecular Carcinogenesis, Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK.
Nat Genet ; 24(2): 197-200, 2000 Feb.
Article em En | MEDLINE | ID: mdl-10655070
ABSTRACT
Testicular germ-cell tumours (TGCT) affect 1 in 500 men and are the most common cancer in males aged 15-40 in Western European populations. The incidence of TGCT has risen dramatically over the last century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT (ref. 7) and a family history of the disease. Brothers of men with TGCT have an 8-10-fold risk of developing TGCT (refs 8,9), whereas the relative risk to fathers and sons is fourfold (ref. 9). This familial relative risk is much higher than that for most other types of cancer. We have collected samples from 134 families with two or more cases of TGCT, 87 of which are affected sibpairs. A genome-wide linkage search yielded a heterogeneity lod (hlod) score of 2.01 on chromosome Xq27 using all families compatible with X inheritance. We obtained a hlod score of 4.7 from families with at least one bilateral case, corresponding to a genome-wide significance level of P=0.034. The proportion of families with UDT linked to this locus was 73% compared with 26% of families without UDT (P=0.03). Our results provide evidence for a TGCT susceptibility gene on chromosome Xq27 that may also predispose to UDT.
Assuntos
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Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Cromossomo X / Germinoma / Predisposição Genética para Doença Tipo de estudo: Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Reino Unido
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Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Cromossomo X / Germinoma / Predisposição Genética para Doença Tipo de estudo: Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Reino Unido