Decreased recovery of replication-competent HIV-1 from peripheral blood mononuclear cell-derived monocyte/macrophages of HIV-positive patients after 3 years on highly active antiretroviral therapy.
AIDS
; 16(9): 1289-92, 2002 Jun 14.
Article
em En
| MEDLINE
| ID: mdl-12045497
ABSTRACT
We studied the release of p24 antigen from peripheral blood mononuclear cell-derived monocyte/macrophages obtained from 13 HIV-positive patients receiving highly active antiretroviral therapy (HAART). Although HIV-infected monocyte/macrophages were detected in 80% of patients after 36 months of continuous treatment, additional exposure to HAART reduced the chance of detecting HIV-releasing monocyte/macrophages. Therefore, after more than 3 years of HAART, recently infected monocytes may play a less important role as a source of emerging HIV-1 upon HAART interruption.
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Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Leucócitos Mononucleares
/
Infecções por HIV
/
HIV-1
/
Fármacos Anti-HIV
/
Macrófagos
Limite:
Humans
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Argentina