Synthesis and use of alpha-silyl-substituted alpha-hydroxyacetic acids.
Org Lett
; 4(13): 2265-7, 2002 Jun 27.
Article
em En
| MEDLINE
| ID: mdl-12074683
ABSTRACT
[reaction see text] Rhodium-catalyzed oxygen transfer was used to generate benzyl 2-silyl-2-oxoacetates in good yields. The hydrogenation of these compounds led to chiral alpha-silyl-substituted alpha-hydroxyacetic acids. Resolution by means of HPLC using a chiral stationary phase afforded an enantiomerically pure representative of this class of compounds, which was successfully applied as a chiral ligand in an asymmetric aldol-type reaction.
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Base de dados:
MEDLINE
Assunto principal:
Glicolatos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Alemanha