Discovery and development of anticancer agents from plants.
J Exp Ther Oncol
; 2(4): 228-36, 2002.
Article
em En
| MEDLINE
| ID: mdl-12416027
ABSTRACT
A novel in vitro assay for the discovery of anticancer agents was used to examine aqueous and organic extracts from 1847 plants collected mainly in the U.S. Southwest and West. The assay results were separated into 5 categories inactive (62%), equally active (36%), equally active and potent (0.5%), solid tumor selective (1.4%), and human selective (0.8%). Extracts from the latter three categories were fractionated using the in vitro assay to biodirect each step. Psorothamnus emoryi extracts were solid tumor selective and yielded two active compounds upon fractionation dalrubone and 5-methoxydalrubone. Calocedrus decurrens was equally active and potent and yielded deoxypodophyllotoxin as the active compound. Linanthus floribundus was human selective and yielded strophanthidin as the active compound. The potential of this assay to discover novel anticancer agents from the active extracts is discussed.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Anticarcinógenos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Exp Ther Oncol
Assunto da revista:
NEOPLASIAS
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos