Disseminated candidiasis and hepatic malarial infection in mannose-binding-lectin-A-deficient mice.
Mol Cell Biol
; 22(23): 8199-203, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12417723
ABSTRACT
To examine the physiological functions of mannose-binding lectin A (MBL-A), we generated mice that were deficient in MBL-A and examined their susceptibilities to the microbial pathogens Candida albicans and Plasmodium yoelii, an accepted experimental malaria model in mouse. We found no differences in the survival rates and fungal burdens of wild-type and MBL-A(-/-) mice with disseminated C. albicans infection. The two mouse strains were also similar in their abilities to resist hepatic accumulation of P. yoelii parasites. We conclude that MBL-A deficiency does not alter resistance to disseminated candidiasis or initial hepatic invasion by P. yoelii.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candidíase
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Plasmodium yoelii
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Lectina de Ligação a Manose
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Fígado
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Malária
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mol Cell Biol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos