Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels.

Beekman, Marian; Heijmans, Bastiaan T; Martin, Nicholas G; Whitfield, John B; Pedersen, Nancy L; DeFaire, Ulf; Snieder, Harold; Lakenberg, Nico; de Knijff, Peter; Frants, Rune R; van Ommen, Gert Jan B; Kluft, Cornelis; Vogler, George P; Slagboom, P Eline; Boomsma, Dorret I

Beekman, Marian; Heijmans, Bastiaan T; Martin, Nicholas G; Whitfield, John B; Pedersen, Nancy L; DeFaire, Ulf; Snieder, Harold; Lakenberg, Nico; de Knijff, Peter; Frants, Rune R; van Ommen, Gert Jan B; Kluft, Cornelis; Vogler, George P; Slagboom, P Eline; Boomsma, Dorret I.

Afiliação

Beekman M; Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. M.Beekman@lumc.nl.

Twin Res ; 6(4): 322-4, 2003 Aug.

Article em En | MEDLINE | ID: mdl-14511440

ABSTRACT

ABSTRACT

Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

Assuntos

Ligação Genética; Lipoproteínas/genética; Locos de Características Quantitativas; Gêmeos/genética; Adolescente; Cromossomos Humanos Par 1; Cromossomos Humanos Par 6; Humanos; Gêmeos Dizigóticos; Gêmeos Monozigóticos

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Base de dados: MEDLINE Assunto principal: Gêmeos / Locos de Características Quantitativas / Ligação Genética / Lipoproteínas Tipo de estudo: Prognostic_studies Limite: Adolescent / Humans Idioma: En Revista: Twin Res Assunto da revista: GENETICA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Holanda

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