ET--phone the pain clinic.
Trends Neurosci
; 27(4): 177-80; discussion 180, 2004 Apr.
Article
em En
| MEDLINE
| ID: mdl-15108686
ABSTRACT
Recent findings by Khodorova et al. demonstrate that the vasoconstrictor endothelin-1 plays an important role in certain nociceptive behaviors in an animal model of pain, through activation of sensory neurons. Endothelin-1 might also have the unexpected capacity to release an opioid from surrounding keratinocytes and thereby inhibit the pain response. Such results suggest that, in the periphery, there are important interactions between sensory nerve terminals and surrounding cells, and that glia and keratinocytes could modulate the perception of environmental stimuli to a greater extent than previously considered.
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Base de dados:
MEDLINE
Assunto principal:
Dor
/
Células Receptoras Sensoriais
/
Receptores de Endotelina
/
Endotelina-1
/
Analgesia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos