Regional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) mice.
Neurosci Lett
; 365(3): 223-7, 2004 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-15246553
ABSTRACT
Recent advance in nuclear magnetic resonance (NMR) microimaging has enabled in vivo cerebral blood volume (CBV) mapping with high spatial resolution. Using an intravascular susceptibility contrast agent and T(2)-weighted magnetic resonance imaging (MRI) on a 9.4T NMR microimager, the regional CBV was measured in mice as the transverse relaxation increase induced by the contrast agent. CBV maps in an Alzheimer's disease mouse model at resting state were obtained and examined. Four-month-old male transgenic mutant APP (V717F, K670N/M671L) mice (N = 10) and littermate wild-type controls (N = 12) were used. Regional analysis of the multi-slice CBV maps revealed statistically significant CBV reductions among the APP mice in cerebral cortex (-9.29%, P = 0.0002), hippocampus (-4.22%, P = 0.02), and thalamus (-5.21%, P = 0.03), indicating an early change of microvasculature in these selected regions. No significant difference was found in olfactory bulb, pons, midbrain, superior colliculus, medulla, and cerebellum.
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Base de dados:
MEDLINE
Assunto principal:
Volume Sanguíneo
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Encéfalo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos