alpha-Synuclein promoter confers susceptibility to Parkinson's disease.
Ann Neurol
; 56(4): 591-5, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15455394
ABSTRACT
Familial Parkinson's disease (PD) has been linked to missense and genomic multiplication mutations of the alpha-synuclein gene (SNCA). Genetic variability within SNCA has been implicated in idiopathic PD in many populations. We now confirm and extend these findings, within a Belgian sample, using a high-resolution map of genetic markers across the SNCA locus. Our study implicates the SNCA promoter in susceptibility to PD, and more specifically defines a minimum promoter haplotype, spanning approximately 15.3kb of sequence, which is overrepresented in patients. Our findings represent a biomarker for PD and may have implications for patient diagnosis, longitudinal evaluation, and treatment.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Regiões Promotoras Genéticas
/
Suscetibilidade a Doenças
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Bélgica