Bradykinin B2 receptor gene (-58T/C) polymorphism influences baroreflex sensitivity in never-treated hypertensive patients.
J Hypertens
; 23(1): 63-9, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15643126
ABSTRACT
BACKGROUND:
Most evidence currently favours a fundamental role of the autonomic nervous system in the pathogenesis of essential hypertension. Recent studies suggest that about 40% of baroreflex variation, an index of cardiac autonomic control, is influenced by genetic factors. METHODS ANDRESULTS:
The aim of this study was to investigate the effect of a common polymorphic variant of the bradykinin B2 receptor gene (B2R; -58T/C) on the autonomic regulation of baroreflex sensitivity (BRS) in 129 mild-moderate never-treated hypertensive patients. No significant differences were found for clinical and biochemical parameters among genotypes. BRS increased with the number of B2R T alleles. B2R genotype was a strong independent predictor of BRS, accounting for 12% of its variation. We suggest that a decrease in the transcription of the bradykinin B2R gene in the presence of the B2R -58C allele could reduce BRS via the diminished effect of bradykinin.CONCLUSIONS:
B2R genotype can explain part of the BRS variation that is unaccounted for by simple anthropometric variables and common risk factors.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Barorreflexo
/
Receptor B2 da Bradicinina
/
Hipertensão
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Hypertens
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália