Commuting between Golgi cisternae--mind the GAP!
Biochim Biophys Acta
; 1744(3): 351-63, 2005 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-15939491
ABSTRACT
Intracellular transport has remained central to cell biology now for more than 40 years. Despite this, we still lack an overall mechanistic framework that describes transport in different parts of the cell. In the secretory pathway, basic questions, such as how biosynthetic cargo traverses the pathway, are still debated. Historically, emphasis was first put on interpreting function from morphology at the ultrastructural level revealing membrane structures such as the transitional ER, vesicular carriers, vesicular tubular clusters, Golgi cisternae, Golgi stacks and the Golgi ribbon. This emphasis on morphology later switched to biochemistry and yeast genetics yielding many of the key molecular players and their associated functions that we know today. More recently, microscopy studies of living cells incorporating biophysics and system analysis has proven useful and is often used to readdress earlier findings, sometimes with surprising outcomes.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Vesículas Revestidas pelo Complexo de Proteína do Envoltório
/
Complexo de Golgi
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Suécia