Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases.
Mod Pathol
; 18(12): 1606-9, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16056245
ABSTRACT
High-risk human papillomaviruses (HPV) are largely implicated in the carcinogenesis of cervical carcinomas. Their role in bronchopulmonary carcinomas is still unclear. In the present study, we have explored 218 fresh frozen lung tumours for the presence of HPV with the Roche line blot assay and for the expression of mRNAs encoding E6 oncoprotein in HPV positive tumours. Only four samples were positive for HPV detection, one poorly differentiated squamous cell carcinoma and three large cell carcinomas. E6 mRNA was undetectable in these four samples. Our data confirm the low prevalence of HPV in lung carcinomas in Western European countries and do not plead in favour of a carcinogenic role for HPV in these carcinomas.
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Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Adenocarcinoma
/
Infecções por Papillomavirus
/
Pulmão
/
Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mod Pathol
Assunto da revista:
PATOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
França