Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 20(11): 1731-5, 2006.
Article
em En
| MEDLINE
| ID: mdl-16676315
ABSTRACT
A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub-structural study have been performed for the differentiation of isocephalomannine (2-debenzoylpaclitaxel-2-pentenoate) from cephalomannine and 7-epi-cephalomannine. A comparative study of the cephalomannine isomers was carried out using molecular ions (MS) and fragmentation patterns (MS/MS) for sub-structural analysis. An attempt has been made to identify isocephalomannine in Cremophor(R) EL formulations.
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Base de dados:
MEDLINE
Assunto principal:
Paclitaxel
/
Taxoides
/
Metais Alcalinos
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Rapid Commun Mass Spectrom
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Índia