Diagnosis of de novo localized thrombotic microangiopathy by surveillance biopsy.
Pediatr Nephrol
; 22(5): 742-6, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17216252
ABSTRACT
Thrombotic microangiopathy has been reported in association with calcineurin inhibitors and less frequently with sirolimus in renal transplant patients. The diagnosis of thrombotic microangiopathy is typically made by diagnostic biopsy in the setting of allograft dysfunction. The finding of thrombotic microangiopathy on surveillance biopsy without a significant elevation of baseline serum creatinine is unusual. The optimal treatment of this disorder remains controversial. Treatment strategies have included dose adjustment, drug substitution, plasmapheresis, and intravenous immunoglobulin G. We report a case of de novo thrombotic microangiopathy diagnosed by surveillance biopsy in a patient without hematologic abnormalities or elevated serum creatinine. This patient had resolution of the renal lesion following conversion from tacrolimus to sirolimus-based immunosuppression.
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Base de dados:
MEDLINE
Assunto principal:
Circulação Renal
/
Trombose
/
Capilares
/
Transplante de Rim
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Nephrol
Assunto da revista:
NEFROLOGIA
/
PEDIATRIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos