Candida glabrata colonizes but does not often disseminate from the mouse caecum.
J Med Microbiol
; 56(Pt 5): 688-693, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17446295
ABSTRACT
Candida glabrata is the second or third most frequent cause of candidaemia. The gastrointestinal tract is considered to be a major portal of entry for systemic candidiasis, but relatively few studies have investigated the pathogenesis of C. glabrata. Experiments were designed to clarify the ability of C. glabrata to disseminate from the mouse intestinal tract. Following oral inoculation, C. glabrata readily colonized the caeca [approx. 10(7) cells (g caecum)(-1)] of antibiotic-treated mice, but extraintestinal dissemination was not detected. Superimposing several mouse models of trauma and/or immunosuppression known to induce dissemination of Candida albicans and other intestinal microbes did not cause C. glabrata to disseminate often, although one exception was mice given high doses of dexamethasone for 4 days. These data support the hypothesis that the antibiotic-treated mouse intestine may be an epidemiological reservoir for C. glabrata and that this yeast tends to disseminate under specific clinical conditions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candidíase
/
Ceco
/
Candida glabrata
Limite:
Animals
Idioma:
En
Revista:
J Med Microbiol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos