Zinc is a novel intracellular second messenger.
J Cell Biol
; 177(4): 637-45, 2007 May 21.
Article
em En
| MEDLINE
| ID: mdl-17502426
ABSTRACT
Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated. Although zinc affects several signaling molecules and may act as a neurotransmitter, it remains unknown whether zinc acts as an intracellular second messenger capable of transducing extracellular stimuli into intracellular signaling events. In this study, we report that the cross-linking of the high affinity immunoglobin E receptor (Fcepsilon receptor I [FcepsilonRI]) induced a release of free zinc from the perinuclear area, including the endoplasmic reticulum in mast cells, a phenomenon we call the zinc wave. The zinc wave was dependent on calcium influx and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase activation. The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcepsilonRI-mediated signaling. Collectively, our findings indicate that zinc is a novel intracellular second messenger.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Sistemas do Segundo Mensageiro
/
Líquido Intracelular
Limite:
Animals
Idioma:
En
Revista:
J Cell Biol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão