Assessing intraepithelial neoplasia and drug safety in cancer-preventive drug development.
Nat Rev Cancer
; 7(7): 508-18, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17568791
ABSTRACT
Despite significant interest from the research community and the population in general, drug approvals for cancer prevention and/or cancer risk reduction are few. This is due, in part, to the requirement that new cancer-preventive drugs must first be shown to be efficacious in reducing cancer incidence or mortality. Moreover, such drugs need to have proven safety for long-term administration. This process can be improved by focusing on precancer (intraepithelial neoplasia) to identify subjects at risk and prove efficacy in shorter, smaller trials as well as on detecting early markers of potential toxicities of chronic exposure to cancer-preventive drug regimens.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma in Situ
/
Anticarcinógenos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos