Purification, identification and activity of phomodione, a furandione from an endophytic Phoma species.
Phytochemistry
; 69(4): 1049-56, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18070629
ABSTRACT
Phomodione, [(4aS(*),9bR(*))-2,6-diacetyl-7-hydroxy-4a,9-dimethoxy-8,9b-dimethyl-4a.9b-dihydrodibenzo[b,d]furan-1,3(2H,4H)-dione], an usnic acid derivative, was isolated from culture broth of a Phoma species, discovered as an endophyte on a Guinea plant (Saurauia scaberrinae). It was identified using NMR, X-ray crystallography, high resolution mass spectrometry, as well as infrared and Raman spectroscopy. In addition to phomodione, usnic acid and cercosporamide, known compounds with antibiotic activity, were also found in the culture medium. Phomodione exhibited a minimum inhibitory concentration of 1.6 microg/mL against Staphylococcus aureus using the disk diffusion assay, and was active against a representative oomycete, ascomycete and basidiomycete at between three and eight micro-grams per mL.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Benzofuranos
/
Actinidiaceae
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos