Prevalence and determinants of elevated apolipoprotein B and dense low-density lipoprotein in youths with type 1 and type 2 diabetes.
J Clin Endocrinol Metab
; 93(3): 735-42, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18089692
ABSTRACT
OBJECTIVE:
The objective of the study was to assess the prevalence and determinants of elevated apolipoprotein B (apoB) and dense low-density lipoprotein (LDL) in United States youth with type 1 or type 2 diabetes.METHODS:
We conducted cross-sectional analyses of apoB concentrations, LDL density, and prevalence of elevated apoB levels and dense LDL from the SEARCH for Diabetes in Youth study, a six-center U.S.-based study of youth with diabetes onset younger than 20 years of age (2657 with type 1 and 345 with type 2).RESULTS:
Among youth with type 1 diabetes, 11% had elevated apoB (>or=100 mg/dl, 1.95 mm/liter), 8% had dense LDL (relative flotation rateCONCLUSIONS:
In youth with type 1 diabetes, elevated apoB and dense LDL were not highly prevalent, whereas elevated apoB and dense LDL were common lipoprotein abnormalities in youth with type 2 diabetes. The prevalence of these risk factors substantially increased with poor glycemic control in both groups, stressing the importance of achieving and maintaining an optimal glucose control.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas B
/
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
/
LDL-Colesterol
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos