Use of platelet growth factors in treating wounds and soft-tissue injuries.
Acta Dermatovenerol Alp Pannonica Adriat
; 16(4): 156-65, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-18204746
ABSTRACT
Tissue repair begins with clot formation and platelet degranulation, which release the growth factors (GFs) necessary for wound repair. Platelet-derived GFs are biologically active substances that enhance tissue repair mechanisms such as chemotaxis, cell proliferation, angiogenesis, extracellular matrix deposition, and remodeling. This review describes the biological background of the topical therapy of wounds and soft-tissue injuries with platelet gel (PG) and PG-derived GFs as well as the success of the clinical studies performed so far. Some other interesting topical applications of PG are also described. Platelet-derivatives represent a promising therapeutic modality, offering opportunities for treatment of wounds, ulcers, soft-tissue injuries, and various other applications in regenerative medicine.
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Base de dados:
MEDLINE
Assunto principal:
Úlcera Cutânea
/
Cicatrização
/
Plaquetas
/
Fator de Crescimento Derivado de Plaquetas
/
Lesões dos Tecidos Moles
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Plasma Rico em Plaquetas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Dermatovenerol Alp Pannonica Adriat
Assunto da revista:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Eslovênia