Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease.
Intensive Care Med
; 34(6): 1109-13, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18283430
ABSTRACT
OBJECTIVE:
To characterize N-terminal pro-brain natriuretic peptide (N-proBNP) and troponin I (TnI) profile following mitral and/or aortic valve surgery and to evaluate correlations with echocardiography measures and outcome criteria. DESIGN ANDSETTING:
Prospective cross-controlled study in a university children's hospital. PATIENTS Twenty children with acquired valvular disease requiring valvular surgery.INTERVENTIONS:
We prospectively studied clinical, biochemical, and echocardiographic characteristics at baseline and 6, 12, 24 h and 3-4 weeks postoperatively.RESULTS:
TnI peaked 6 h after surgery and remained elevated during the first 24 h. N-proBNP was significantly lower 3-4 weeks after surgery than during the perioperative period. Overall, N-proBNP was correlated with the Pediatric Heart Failure Index, left ventricle shortening fraction, left atrium to aorta ratio, left ventricle mass index, end-systolic wall stress, and with outcome measures such as inotropic score, duration of inotropic support, and ICU length of stay. Preoperative N-proBNP was significantly more elevated in patients with complicated outcome than in patients with uneventful postoperative course.CONCLUSIONS:
In pediatric valvular patients, perioperative N-proBNP is a promising risk stratification predicting factor. It is correlated with evolutive echocardiographic measures, need for inotropic support, and ICU length of stay.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Peptídeo Natriurético Encefálico
/
Doenças das Valvas Cardíacas
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
Idioma:
En
Revista:
Intensive Care Med
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Suíça