PDEs as drug targets for CNS immune disorders.
Curr Opin Investig Drugs
; 9(7): 744-53, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18600580
ABSTRACT
PDEs are important second messenger systems governing a host of cellular functions involved in neural signal transduction in the CNS and inflammatory cell signaling in the immune system. The contributions of PDE family members as novel treatments that target neuroinflammation as a pathophysiological process in the neuropathogenesis of diverse neurological and psychiatric brain disorders with prominent immune system correlates are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Fosfodiesterase
/
Diester Fosfórico Hidrolases
/
Doenças Autoimunes do Sistema Nervoso
/
Inibidores Enzimáticos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Investig Drugs
Assunto da revista:
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Canadá