Mechanisms of benefit of angiotensin receptor blockers in coronary atherosclerosis.
Am J Med Sci
; 336(3): 270-7, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18794623
ABSTRACT
There is mounting evidence that dysfunction of the renin angiotensin system is a vital contributor to the development of atherosclerosis. Nonetheless, the efficacy of angiotensin receptor blockers on clinical outcomes in patients with coronary atherosclerosis has been limited. This review will examine the potential mechanisms by which angiotensin receptor blockers potentially affect several key steps in the atherosclerotic process endothelial function, inflammation, and thrombosis. Despite the mounting evidence for these agents on multiple processes in the development of atherosclerosis, their clinical utility in patients with coronary artery disease remains unclear.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Bloqueadores do Receptor Tipo 1 de Angiotensina II
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Am J Med Sci
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos