Correlates of PLMs variability over multiple nights and impact upon RLS diagnosis.
Sleep Med
; 10(6): 668-71, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19022704
ABSTRACT
OBJECTIVE:
Night-to-night variability of periodic leg movements (PLMs) in restless legs syndrome (RLS) was examined to define the range of intra-subject values, impact upon diagnosing RLS, and clinical correlates.METHODS:
Twenty RLS patients were monitored for 10-15 nights using a validated, tri-axial accelerometer worn on the ankle.RESULTS:
The mean difference in PLMs index (PLMI) between the lowest and highest night was 25.1/h (range 3.9-73.8). Inter-subject differences accounted for nearly five times the variance in PLMI relative to between nights within an individual. Based on a single night of recording, PLMI criterion thresholds of 5, 10, and 15/h were exceeded on approximately 70.1%, 51.9% and 34.1% of individual nights among these patients. Based on five randomly sampled nights of recordings, the likelihood that such thresholds were met on at least a single night increased to 91.2%, 80.8% and 62.7%, respectively. Women exhibited greater variability.CONCLUSIONS:
Variability in PLMs within RLS subjects was substantial, yet individuals' characteristic PLM level represented a quantitative trait. Variability was unrelated to age or scores on scales of RLS severity, sleepiness, functional status, and mood. A larger number of recording nights increased the likelihood that any criterion was reached.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome das Pernas Inquietas
/
Síndrome da Mioclonia Noturna
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Sleep Med
Assunto da revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos