Heterogeneity of changes in lymphoproliferative ability with increasing age.
Exp Gerontol
; 26(2-3): 269-79, 1991.
Article
em En
| MEDLINE
| ID: mdl-1915696
ABSTRACT
Although mean mitogen-induced lymphoproliferation decreases with increased age, the response of individual subjects demonstrates great heterogeneity. Results of this study clearly illustrate that individual variation is apparent not only in the level of proliferation, but also in the amount of interleukin-2 (IL-2) detectable after mitogen stimulation. Further, addition of exogenous IL-2 significantly increases proliferation in only about one third of elderly subjects. Data from inbred strains of rats housed under identical environmental conditions indicate that although genetic factors greatly influence both the level of proliferation and the rate of decline with age, variation occurs even within one inbred strain of rat.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Ativação Linfocitária
Limite:
Adult
/
Aged
/
Aged80
/
Animals
/
Humans
Idioma:
En
Revista:
Exp Gerontol
Ano de publicação:
1991
Tipo de documento:
Article