Expression of Twist in different subtype of ameloblastomas.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 108(4): 565-70, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19699120
ABSTRACT
OBJECTIVE:
The objective of this study was to investigate the pattern of Twist expression in a series of ameloblastomas, and to study the possible role of Twist in the bone destruction and local invasiveness of ameloblastoma variants. STUDYDESIGN:
Immunohistochemical study was performed for Twist protein in 53 ameloblastomas (32 solid/multicystic [SA] and 21 unicystic [UA]).RESULTS:
The salient finding was that expression of Twist was related to the histological subtype of tumors, as there was a higher expression in SA (14/32, 43.75%) as compared to UA (4/21, 19.05%) (P < .05). Both nuclei and cytoplasm positivities were detected in positive cases, whereas cytoplasmic staining was diffused and predominant. Cases rich in stromal cells showed a higher percentage of positive cells than those with less stroma.CONCLUSIONS:
Our results suggest that Twist expression might be associated with invasion in ameloblastoma variants, and stromal cells might play a regulatory role during tumor development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Ameloblastoma
/
Neoplasias Maxilomandibulares
/
Proteína 1 Relacionada a Twist
Limite:
Humans
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article